MVD-1 is under clinical development by Eolo Pharma and currently in Phase I for Obesity. According to GlobalData, Phase I drugs for Obesity have a 59% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. MVD-1 overview MVD-1 is under development for the treatment of obesity, type 2 diabetes, metabolic dysfunction-associated steatohepatitis (MASH), hypertension, amyotrophic lateral sclerosis (ALS), unspecified metabolic disorders and Alzheimer's disease. It is being developed based on eolo pharma's technology. It is administered through oral route. Eolo Pharma overview Eolo Pharma, is developing multiple drugs that stop low grade chronic inflammation. The company is headquartered in Argentina. For a complete picture of MVD-1’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .bookmaker lines 。

ATLANTA — Jimmy Carter, the peanut farmer who tried to restore virtue to the White House after the Watergate scandal and Vietnam War, then rebounded from a landslide defeat to become a global advocate of human rights and democracy, has died. He was 100 years old. The Carter Center said the 39th president died Sunday, more than a year after entering hospice care, at his home in Plains, Georgia, where he and his wife, Rosalynn, who died in November 2023, lived most of their lives. A moderate Democrat, Carter ran for president in 1976 as a little-known Georgia governor with a broad grin, effusive Baptist faith and technocratic plans for efficient government. His promise to never deceive the American people resonated after Richard Nixon’s disgrace and U.S. defeat in southeast Asia. “If I ever lie to you, if I ever make a misleading statement, don’t vote for me. I would not deserve to be your president,” Carter said. Carter’s victory over Republican Gerald Ford, whose fortunes fell after pardoning Nixon, came amid Cold War pressures, turbulent oil markets and social upheaval over race, women’s rights and America’s role in the world. His achievements included brokering Mideast peace by keeping Egyptian President Anwar Sadat and Israeli Prime Minister Menachem Begin at Camp David for 13 days in 1978. But his coalition splintered under double-digit inflation and the 444-day hostage crisis in Iran. His negotiations ultimately brought all the hostages home alive, but in a final insult, Iran didn’t release them until the inauguration of Ronald Reagan, who had trounced him in the 1980 election. Humbled and back home in Georgia, Carter said his faith demanded that he keep doing whatever he could, for as long as he could, to try to make a difference. He and Rosalynn co-founded The Carter Center in 1982 and spent the next 40 years traveling the world as peacemakers, human rights advocates and champions of democracy and public health. Awarded the Nobel Peace Prize in 2002, Carter helped ease nuclear tensions in North and South Korea, avert a U.S. invasion of Haiti and negotiate cease-fires in Bosnia and Sudan. By 2022, the center had monitored at least 113 elections around the world. Carter was determined to eradicate guinea worm infections as one of many health initiatives. Swinging hammers into their 90s, the Carters built homes with Habitat for Humanity. Article continues after... Cross|Word Flipart Typeshift SpellTower Really Bad Chess The common observation that he was better as an ex-president rankled Carter. His allies were pleased that he lived long enough to see biographers and historians revisit his presidency and declare it more impactful than many understood at the time. Propelled in 1976 by voters in Iowa and then across the South, Carter ran a no-frills campaign. Americans were captivated by the earnest engineer, and while an election-year Playboy interview drew snickers when he said he “had looked on many women with lust. I’ve committed adultery in my heart many times,” voters tired of political cynicism found it endearing. The first family set an informal tone in the White House, carrying their own luggage, trying to silence the Marine Band’s traditional “Hail to the Chief” and enrolling daughter, Amy, in public schools. Carter was lampooned for wearing a cardigan and urging Americans to turn down their thermostats. But Carter set the stage for an economic revival and sharply reduced America’s dependence on foreign oil by deregulating the energy industry along with airlines, trains and trucking. He established the departments of Energy and Education, appointed record numbers of women and nonwhites to federal posts, preserved millions of acres of Alaskan wilderness and pardoned most Vietnam draft evaders. Emphasizing human rights, he ended most support for military dictators and took on bribery by multinational corporations by signing the Foreign Corrupt Practices Act. He persuaded the Senate to ratify the Panama Canal treaties and normalized relations with China, an outgrowth of Nixon’s outreach to Beijing. But crippling turns in foreign affairs took their toll. When OPEC hiked crude prices, making drivers line up for gasoline as inflation spiked to 11%, Carter tried to encourage Americans to overcome “a crisis of confidence.” Many voters lost confidence in Carter instead after the infamous address that media dubbed his “malaise” speech, even though he never used that word. After Carter reluctantly agreed to admit the exiled Shah of Iran to the U.S. for medical treatment, the American Embassy in Tehran was overrun in 1979. Negotiations to quickly free the hostages broke down, and then eight Americans died when a top-secret military rescue attempt failed. Carter also had to reverse course on the SALT II nuclear arms treaty after the Soviets invaded Afghanistan in 1979. Though historians would later credit Carter’s diplomatic efforts for hastening the end of the Cold War, Republicans labeled his soft power weak. Reagan’s “make America great again” appeals resonated, and he beat Carter in all but six states. Born Oct. 1, 1924, James Earl Carter Jr. married fellow Plains native Rosalynn Smith in 1946, the year he graduated from the Naval Academy. He brought his young family back to Plains after his father died, abandoning his Navy career, and they soon turned their ambitions to politics. Carter reached the state Senate in 1962. After rural white and Black voters elected him governor in 1970, he drew national attention by declaring that “the time for racial discrimination is over.” Carter published more than 30 books and remained influential as his center turned its democracy advocacy onto U.S. politics, monitoring an audit of Georgia’s 2020 presidential election results. After a 2015 cancer diagnosis, Carter said he felt “perfectly at ease with whatever comes.” “I’ve had a wonderful life,” he said. “I’ve had thousands of friends, I’ve had an exciting, adventurous and gratifying existence.”

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Men's Health Awareness Month: Can Vitamin Deficiency Impact Male Reproductive Health? Expert Weighs InNORTH BAY, Ont. — Dalyn Wakely scored twice as the Barrie Colts topped the North Bay Battalion 3-1 in Ontario Hockey League play on Sunday. Zach Wigle had the other goal for Barrie. Briir Long replied for North Bay. 67'S 5 PETES 4 PETERBOROUGH, Ont. — Will Gerrior scored the game-winning goal at 19:49 of the third period as the 67's edged the Petes. It was his second goal of the game. Cooper Foster, Henry Mews and Chris Barlas added singles in Ottawa's victory. SPITFIRES 10 GREYHOUNDS 6 SAULT STE. MARIE, Ont. — Cole Davis had a hat trick as the Windsor Spitfires topped the Sault Ste. Marie Greyhounds. Liam Greentree scored twice for the Spitfires. RANGERS 3 WOLVES 2 SUDBURY, Ont. — Adrian Misaljevic's overtime winner gave the Rangers a victory over the Wolves. Luke Ellinas and Haeden Ellis scored in regulation for Kitchener. KNIGHTS 4 FIREBIRDS 1 FLINT, Mich. — Noah Aboflan had a goal and an assist as the London Knights downed Flint Firebirds. PJ Fagan II, Henry Brzustewicz and Andoni Fimis also scored for London. SPIRIT 6 ICEDOGS 3 SAGINAW, Mich. — Carson Harmer scored three goals as the Saginaw Spirit defeated the Niagara IceDogs. Calem Mangone added two goals while Ethan Hay tallied once for Saginaw. GENERALS 4 FRONTENACS 2 OSHAWA, Ont. — Luca Marrelli had a goal and an assist as the Oshawa Generals downed the Kingston Frontenacs. Owen Griffin, Lauri Sinivuori and Colby Barlow also scored for Oshawa. This roundup was generated automatically with a CP-developed application. This report by The Canadian Press was first published Dec. 29, 2024. The Canadian Press

Trump shooting task force unveils bombshell final report on 'preventable' assassination attempt By KATELYN CARALLE, SENIOR U.S. POLITICAL REPORTER IN WASHINGTON, D.C. Published: 15:44 EST, 10 December 2024 | Updated: 16:32 EST, 10 December 2024 e-mail 21 View comments The House Assassination task force released its final and longawait report on Tuesday. The 180-page report claims the deadly shooting at Donald Trump 's Butler, Pennsylvania rally on July 13 was 'preventable and should not have happened.' It was released just days after its final public meeting last week where Acting Secret Service Director Ronald Rowe got into a screaming match with Rep. Pat Fallon (R-Texas). Rowe did acknowledge at the hearing the agency's 'abject failure' in the July shooting. The 13-member panel was created by a House vote shortly after the first assassination attempt over the summer. And a few months later they were asked to also look into the second incident. The group concluded that there was no single failure that allowed shooter Thomas Matthew Crooks to fire at Trump, but 'various' decisions and moments that created an ideal situation for the assassination attempt. The Task Force on the Attempted Assassination of Donald Trump released a series of recommendations it feels will help prevent future incidents. Members of the task force visited both sites where men tried to take out the former – and now future – president. The House Assassination Task Force released its final report on the two attempts on Donald Trump's life The task force said it conducted 46 interviews and reviewed 18,000 pages of documents. Crooks, who was 20 when he was shot dead by a Secret Service counter sniper, killed one rally goer, injured two others and was able to strike Trump in the right ear before he was neutralized by the former president's protective detail. '[T]he former President—and everyone at the campaign event—were exposed to grave danger,' the committee wrote. 'Conversely, the events that transpired on September 15, 2024, in West Palm Beach, Florida, demonstrated how properly executed protective measures can foil an attempted assassination,' they added. The bipartisan task force was created to investigate the July 13 attack that came just centimeters away from ending Trump's life. But when a second assassination plot was foiled just two months later on September 15, the panel was also asked to include that incident in its probe. While Crooks was able to get just several hundred feet in range of Trump with a rifle and discharge several shots , Ryan Wesley Routh, 58, didn't even fire a shot before a Secret Service agent opened fire in his direction. Routh was posted outside Trump's West Palm Beach golf course in the shrubs when he pointed the barrel of his firearm through the fencing and bush. An agent surveying the green a few holes ahead of the then-2024 presidential candidate spotted the scope and fired in the direction of the threat. Routh fled the scene but was captured shortly after and taken into custody. His firearm, backpacks with bulletproof materials and a GoPro camera were recovered from where he was camping out since the middle of the night. The Assassination Task Force said the second incident was an example of what should be done by the Secret Service to best guard their protectees. While the first assassination attempt was used as an example of how a series of failures can lead to a deadly situation. Read More BREAKING NEWS Republican lawmaker EXPLODES at Secret Service boss The report comes just days after their final hearing, which devolved as Rep. Fallon got into a fiery back-and-forth with Acting Director Rowe. An impassioned shouting match broke out after Fallon struck a nerve when he pressed Rowe about security measures in place to protect Trump, Joe Biden and Kamala Harris at the September 11 remembrance this year. It led to a bitter argument between the two men at the hearing on Thursday, which was supposed to be focused on the security failures surrounding Trump's protective detail. But the conversation turned to what Fallon considered to be another Secret Service security problem two months after the first attempt – and just days before the second. Fallon said the agent in charge of the detail should have been stationed physically closer to Trump, Biden and Harris when they all attended a 9/11 commemoration event at Ground Zero. When asked about why the SAIC was out of range, Rowe insisted that he and other members of the detail were just outside of view of the image Fallon had blown up to exhibit at the hearing. Rep. Pat Fallon (R-Texas) got into a heated screaming match with U.S. Secret Service Acting Director Ronald Rowe during the final House Assassination Task Force hearing 'Do not invoke 9/11 for political purposes, congressman,' Rowe yelled at Fallon over a barrage of cross-shouting after the lawmaker displayed an image of the Acting Director at the Ground Zero service this year 'That is the day that we remember the more than 3,000 people that have died on 9/11,' Rowe said, starting to raise his voice. 'I actually responded to Ground Zero. I was there going through the ashes of the World Trade Center,' he went on. When Fallon tried to cut in, Rowe did not back down, causing the congressman to begin shouting. 'I'm not asking you that. I'm asking you, were you the special agent in charge?! You were not,' Fallon charged. 'Do not invoke 9/11 for political purposes, congressman!' Rowe was heard yelling over a barrage of cross-shouting. 'I'm trying to ask a question. Don't try to bully me!' Fallon screamed and pointed at the witness. 'You are out of line, congressman!' Rowe fired back. 'Way out of line.' Pennsylvania Texas Thomas Matthew Crooks Share or comment on this article: Trump shooting task force unveils bombshell final report on 'preventable' assassination attempt e-mail Add commentCapital Power Announces $350 Million Bought Offering of Common SharesInside ancient city dubbed ‘Manhattan of the desert’ with skyscrapers made from MUD now facing risk of collapse

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Energean plc ( LON:ENOG – Get Free Report )’s stock price was up 0.4% during trading on Friday . The company traded as high as GBX 1,031 ($12.97) and last traded at GBX 1,016 ($12.78). Approximately 173,076 shares were traded during trading, a decline of 70% from the average daily volume of 581,400 shares. The stock had previously closed at GBX 1,012 ($12.73). Analyst Upgrades and Downgrades Separately, Berenberg Bank downgraded Energean to a “hold” rating and dropped their price target for the stock from GBX 1,175 ($14.79) to GBX 1,045 ($13.15) in a research report on Thursday, December 5th. Get Our Latest Stock Report on Energean Energean Stock Up 0.4 % Energean Announces Dividend The company also recently declared a dividend, which will be paid on Monday, December 30th. Stockholders of record on Thursday, December 5th will be issued a dividend of $0.30 per share. The ex-dividend date is Thursday, December 5th. This represents a dividend yield of 2.17%. Energean’s dividend payout ratio (DPR) is presently 7,826.09%. Insider Activity at Energean In other Energean news, insider Matthaios Rigas purchased 40,000 shares of the firm’s stock in a transaction on Wednesday, October 2nd. The shares were purchased at an average cost of GBX 850 ($10.70) per share, with a total value of £340,000 ($427,834.40). Insiders own 24.40% of the company’s stock. Energean Company Profile ( Get Free Report ) Energean plc engages in the exploration, development, and production of oil and gas. It operates through four segments: Europe, Israel, Egypt, and New Ventures. The company holds interests in the Eastern Mediterranean. Its flagship project is the Karish project located in Israel. It also provides financing services; and holds a gas transportation license. Featured Articles Receive News & Ratings for Energean Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Energean and related companies with MarketBeat.com's FREE daily email newsletter .

From Jelly Roll to TWICE, top acts hit 'Amazon Music Live' to spotlight their upcoming projects