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BNP Paribas Financial Markets lifted its stake in Integra LifeSciences Holdings Co. ( NASDAQ:IART – Free Report ) by 824.5% in the third quarter, according to its most recent Form 13F filing with the Securities & Exchange Commission. The firm owned 111,775 shares of the life sciences company’s stock after acquiring an additional 99,685 shares during the quarter. BNP Paribas Financial Markets owned 0.14% of Integra LifeSciences worth $2,031,000 as of its most recent filing with the Securities & Exchange Commission. Several other hedge funds have also recently made changes to their positions in IART. Cooke & Bieler LP lifted its holdings in Integra LifeSciences by 12.4% in the second quarter. Cooke & Bieler LP now owns 3,514,281 shares of the life sciences company’s stock valued at $102,406,000 after acquiring an additional 388,710 shares during the period. Dimensional Fund Advisors LP lifted its stake in shares of Integra LifeSciences by 0.7% in the 2nd quarter. Dimensional Fund Advisors LP now owns 1,785,009 shares of the life sciences company’s stock worth $52,014,000 after purchasing an additional 12,766 shares during the period. Charles Schwab Investment Management Inc. lifted its stake in shares of Integra LifeSciences by 15.3% in the 3rd quarter. Charles Schwab Investment Management Inc. now owns 944,282 shares of the life sciences company’s stock worth $17,158,000 after purchasing an additional 125,620 shares during the period. D. E. Shaw & Co. Inc. boosted its holdings in shares of Integra LifeSciences by 64.6% in the second quarter. D. E. Shaw & Co. Inc. now owns 855,352 shares of the life sciences company’s stock worth $24,925,000 after buying an additional 335,557 shares during the last quarter. Finally, AQR Capital Management LLC grew its position in Integra LifeSciences by 90.9% during the second quarter. AQR Capital Management LLC now owns 611,798 shares of the life sciences company’s stock valued at $17,436,000 after buying an additional 291,326 shares during the period. 84.78% of the stock is owned by hedge funds and other institutional investors. Integra LifeSciences Stock Up 1.0 % Shares of IART opened at $24.10 on Friday. Integra LifeSciences Holdings Co. has a 12-month low of $16.81 and a 12-month high of $45.42. The company has a current ratio of 1.20, a quick ratio of 0.73 and a debt-to-equity ratio of 0.79. The company has a market capitalization of $1.86 billion, a PE ratio of -267.75, a price-to-earnings-growth ratio of 0.82 and a beta of 1.15. The business’s 50 day moving average is $21.44 and its 200 day moving average is $23.88. Insider Activity In related news, EVP Michael J. Mcbreen sold 1,700 shares of the business’s stock in a transaction dated Monday, December 2nd. The stock was sold at an average price of $24.16, for a total value of $41,072.00. Following the sale, the executive vice president now directly owns 56,182 shares in the company, valued at approximately $1,357,357.12. The trade was a 2.94 % decrease in their ownership of the stock. The transaction was disclosed in a filing with the Securities & Exchange Commission, which is accessible through this hyperlink . Company insiders own 3.10% of the company’s stock. Analysts Set New Price Targets Several research analysts have recently weighed in on the stock. Truist Financial dropped their price target on shares of Integra LifeSciences from $26.00 to $21.00 and set a “hold” rating on the stock in a research note on Monday, October 14th. Bank of America lowered their target price on Integra LifeSciences from $26.00 to $18.00 and set an “underperform” rating on the stock in a research report on Monday, October 7th. Morgan Stanley initiated coverage on Integra LifeSciences in a report on Monday, December 2nd. They set an “underweight” rating and a $20.00 price target for the company. BTIG Research raised Integra LifeSciences from a “sell” rating to a “neutral” rating in a research note on Monday, October 7th. Finally, Citigroup boosted their price objective on Integra LifeSciences from $16.00 to $22.00 and gave the company a “sell” rating in a research note on Tuesday, November 5th. Three investment analysts have rated the stock with a sell rating, five have issued a hold rating and one has issued a buy rating to the stock. Based on data from MarketBeat, the company presently has a consensus rating of “Hold” and a consensus target price of $23.00. Read Our Latest Report on Integra LifeSciences Integra LifeSciences Profile ( Free Report ) Integra LifeSciences Holdings Corporation manufactures and sells surgical instruments, neurosurgical products, and wound care products for use in neurosurgery, neurocritical care, and otolaryngology. It operates in two segments, Codman Specialty Surgical and Tissue Technologies. The company offers neurosurgery and neuro critical care products, including tissue ablation equipment, dural repair products, cerebral spinal fluid management devices, intracranial monitoring equipment, and cranial stabilization equipment; and surgical headlamps and instrumentation, as well as after-market services. See Also Five stocks we like better than Integra LifeSciences What Are Some of the Best Large-Cap Stocks to Buy? Fast-Growing Companies That Are Still Undervalued What Makes a Stock a Good Dividend Stock? Top Cybersecurity Stock Picks for 2025 Bank Stocks – Best Bank Stocks to Invest In Archer or Joby: Which Aviation Company Might Rise Fastest? Want to see what other hedge funds are holding IART? Visit HoldingsChannel.com to get the latest 13F filings and insider trades for Integra LifeSciences Holdings Co. ( NASDAQ:IART – Free Report ). Receive News & Ratings for Integra LifeSciences Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Integra LifeSciences and related companies with MarketBeat.com's FREE daily email newsletter .

The Miami Dolphins and New York Jets combined to make NFL history on Sunday. During Miami's win over New York, not only did the Dolphins keep their faint playoff hopes alive with their overtime win, but the two teams ended up giving us a final score that's never been seen before in NFL history. The Dolphins sent the game to overtime when Jason Sanders hit a 52-yard field goal on the final play of regulation to tie things up at 26. Miami then won the toss in overtime and decided to take the ball, which ended up being a good decision, because it was able to march 70 yards down the field to score the game-winning touchdown. The 10-yard scoring throw from Tua Tagovailoa to Jonnu Smith was a big one because it gave us a scorigami: The 32-26 final marked the first time in NFL history that a game had ever ended with that exact score. Score Update: NYJ 26 - 32 MIA Final That's Scorigami!! It's the 1089th unique final score in NFL history. As you can see above, it's the 1,089th unique final score in NFL history. If this had been a playoff game, the Dolphins would have had to attempt an extra point in overtime, and in that case, it would NOT have been a scorigami because 33-26 has happened before. However, under the NFL's overtime rules for a regular-season game, if a team scores on a touchdown on the opening drive of ovetime, then the game is over and there's no extra point attempt. Tua Tagovailoa was nearly perfect in overtime, going 6 of 7 for 67 yards and a touchdown. Overall, Tua threw for 331 yards and two touchdowns. Aaron Rodgers also had a big game: With 339 yards, the Jets QB hit the 300-yard mark for the first time since December 2021. As for the unique final score, there have been five scorigamis this season, and the Jets have actually been involved in two of them. They also had the first scorigami of the year back in Week 1 during a 32-19 loss to the San Francisco 49ers . As for the Dolphins, this was their fourth scorigami since the start of the 2023 season, but their first one of 2024. With just five scorigamis through 14 weeks, it's becoming unlikely that we're going to see the 2024 season surpass the total from 2023 when there were nine scorigamis.TeraWulf Announces November 2024 Production and Operations Update

Tech Tumble! Dow Dips Dramatically.Adam Pemble, an Associated Press video journalist who covered some of the biggest global news of the past two decades, from earthquakes and conflicts to political summits and elections, has died. He was 52. Pemble died Thursday in Minneapolis surrounded by friends and family, according to his friend Mike Moe, who helped care for him in the final weeks of his fight against cancer. Known for bringing stories alive with his camera, Pemble epitomized the best of television news traditions, casting a curious and compassionate lens onto the lives of the people and communities whose stories he told. He joined the AP in 2007 in New York before moving to Prague in 2011 to help launch AP’s first cross-format operation combining photography, text stories and video. He enhanced Eastern European news coverage, creating distinctive stories highlighting the region’s culture and society. “Adam was an incredibly talented and passionate journalist and an empathetic storyteller. He had this amazing ability to get anyone to talk to him on camera, which I attribute to the Midwestern charm he embodied throughout his life.” said Sara Gillesby, AP’s Director of Global Video and Pemble’s former manager in New York when he joined the AP. “He was the best of us.” Pemble was born in Saint Louis Park, Minnesota, in 1972 and grew up in Minneapolis. After graduating with a degree in mass communications from Minnesota State University Moorhead, he started his journalism career in 1997 at KVLY, a television station in Fargo, North Dakota, and later worked at WCCO in Minneapolis. “He had the skills of the old-school camera people to meet a deadline and turn a beautiful story,” said Arthur Phillips, a cameraman who worked with Pemble at WCCO. “But he had a calling for greater things.” Moving to New York, Pemble covered some of the biggest stories in the city, including the trial of Bernie Madoff, interviews with former Iranian President Mahmoud Ahmadinejad and with then-real estate developer, now U.S. president-elect, Donald Trump. He went to Haiti to cover the aftermath of the 2010 earthquake, where he captured shocking images of devastation. A few weeks later he was in Vancouver, covering the Winter Olympics. With his transfer to Prague, Pemble quickly became the go-to video journalist deployed to the biggest news events in Europe, interviewing government leaders, covering violent protests, the aftermath of terror attacks and numerous national elections across the continent. “An inquiring mind, a keen eye and a healthy skepticism for those in power who tried to spin away from the truth all combined to make Adam’s stories as rich in colour as he was in character,” said Sandy MacIntyre, former AP head of global video. “Time and again he was asked to do the impossible and without fail he delivered the exceptional.” ”But more than all of that, he was the colleague and friend you wanted by your side because if Adam was there we knew we were going to be the winning team.” As civil unrest rocked Ukraine in 2014, Pemble reported from Kyiv and later Donetsk, where he covered the first Russian-backed demonstrations before spending weeks in Crimea during Russia’s annexation of the strategic peninsula. His video reports included the last remaining Ukrainian sailors loyal to Kyiv, who had finally abandoned their ship and came ashore. With the Russian national anthem playing from a car in the background, his final shot showed two distraught sailors heckled as they walked away. Pemble returned to Ukraine following Russia’s invasion of the country in 2022. Among his many assignments was March 2023 AP interview by Executive Editor Julie Pace with across Ukraine to cities near some of the fiercest fighting. “Adam showed up to every assignment with enthusiasm, creativity and commitment to his work and his colleagues. He loved what he did, and so many of us at AP are better for having worked alongside him,” Pace said. When not deployed overseas, set his camera’s gaze on his new home in the Czech Republic, offering insight into the traditions and unique stories of Eastern Europe. From Christmas carp fishing at sunrise to graffiti artists in Prague to the intimate story of a Slovak priest challenging the celibacy rules of the Catholic Church, he brought his unmistakable style. He worked with a traditional large broadcast camera in an era where many video shooters shifted to smaller, lighter cameras. He always put himself in the right place to let reality unfold like “an old school analog painter in an often fast and furious digital age,” former AP cameraman Ben Jary recalled. Pemble’s interest in visual storytelling led to experimenting with new technologies, including aerial videography. In 2015, he was the first major news agency camera operator to film live drone footage when reporting on the migration crisis in the Balkans. An avid gardener who planted trees and chilis on his rooftop in Prague, he was adventurous in the kitchen and especially proud of his vegan “meatloaf,” friends said. He loved a seedy dive bar as much as a Michelin restaurant and foods as varied as charcoal choux pastry with truffle creme and his favourite road trip junk food, Slim Jim’s jerky and Salted Nut Rolls. Pemble’s wit, wisdom, energy and positivity enriched the lives and experiences of those around him, friends and colleagues recalled. “If someone asked me to see a picture of quiet strength and courage, dignity and grace, and most of all kindness, I would show them a picture of a man for all seasons,” said Dan Huff, a Washington-based AP video journalist, “I would show them a picture of Adam Pemble.”Traveling this holiday season? 10 things the TSA wants you to know

It’s been awhile since Niagara Wheatfield went into the season not knowing who was going to score late in games — they’ve graduated a 1,000-point scorer three years in a row. But, things are different now. After losing nine seniors at the end of the 2023-24 season, many of whom played a part in winning Class A1 in 2022, it became clear that there was some rebuilding needed at Niagara Wheatfield if they want to be crowned champions anytime soon. The loss of Luke Walck, a two-time All-Niagara Frontier League player who was one vote away from player of the year last season, is sure to not only hurt, but change, the Falcon’s offense. Now 1-6 on a three-game skid, Niagara Wheatfield is off to its worst start since the 2019-20 season, when the team went 2-5 and finished the season 9-12 overall. There's only one starter with varsity experience, Cameron Gruarin, who made it into the lineup after an injury halfway through his junior season. Starting besides him is a seventh-grader and three juniors. “We played so well the other night against North Tonawanda and then all of a sudden we just kinda had this moment and it was like, ‘Holy cow. What are we doing out there?,’” Niagara Wheatfield head coach Erik O’Bryan. “And it's just a lack of experience.” The team is very inexperienced, but that doesn’t mean good things can’t happen, it just might take a little longer because they have growing pains to work through. There’s no big man like the 6-foot-5 Walck to rely on this year so the team has more shooters so they’re looking at a quick concept on the court. The Falcons weren’t able to all get together over the summer either, as so many of the players are multi-sport athletes. While it helps to have a team of athletes, it is no doubt a struggle when the group lacks individual experience, and experience playing as a team. While Gruarin’s experience makes him the unquestioned leader, he’s still learning with the rest of the group. With the Falcons all being thrown in the fire, they have the opportunity to rise or burn, but either way it is something they will do together. The lack of experience allows for the opportunity to be coached and learn things the way the coaches intend, hopefully minimizing bad habits and building team chemistry along the way. Niagara Wheatfield has a history of turning it around in recent years. O’Bryan’s teams have gone 20-16 before Jan. 1 dating back to 2019-20 — excluding the COVID-19 spring season in 2021 — and have rebounded to go a combined 46-17 in the New Year. “Obviously losing is definitely not the goal, but at the end of the day as long as we’re getting better, and each game has been much better,” Gruarin said. “Right now losing is fine, as long as we keep growing, I'm sure we’ll start winning by the middle of the season.” The energy presented at practices and games each day also helps NW stay focused and positive, two things that can help them improve their slow start to the season. The team is seeing improvement the more they play together and as team chemistry gets stronger. There are shots they trust each other to make now that they might’ve been hesitant with at the start of the year, and the team has already improved since their 37-77 loss to McKinley High School to open up the season. “As the season goes on our games keep getting closer and closer and I can see the fight and energy in our team as we keep going along and keep building this team,” Gruarin said.

Published 5:28 pm Tuesday, November 26, 2024 By Data Skrive The Cornell Big Red versus the Syracuse Orange is one of many solid options on Wednesday in college basketball play — suggested picks against the spread for 10 games are available below. Watch men’s college basketball, other live sports and more on Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Use our link to sign up for a free trial. Bet on this or any men’s college basketball matchup at BetMGM. Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER .None

Traveling this holiday season? 10 things the TSA wants you to know

Work and pensions minister Sir Stephen Timms said the move aims to drive “real improvements” for disabled people, whom the ministers will be encouraged to engage with on a regular basis. He told the Commons: “I am very pleased to be able to announce today the appointment of new lead ministers for disability in each Government department, they will represent the interests of disabled people, champion disability inclusion and accessibility within their departments. “I’m going to chair regular meetings with them and will encourage them to engage directly with disabled people and their representative organisations, as they take forward their departmental priorities. “And I look forward to this new group of lead ministers for disability together driving real improvements across Government for disabled people.” This came during an adjournment debate on International Day of Persons with Disabilities, where Liberal Democrat MP Steve Darling raised concerns about “floating bus stops”, which have a cycle lane between the stop and the pavement. Intervening, the MP for Torbay, who is registered blind, said: “The Government needs to ban floating bus stops.” Sir Stephen said: “I do think this issue about floating bus stops is an important issue which we need to work across Government to reflect on.” Labour MP Debbie Abrahams, who led the debate, had earlier criticised the lack of accessibility for disabled people on trains. The Oldham East and Saddleworth MP said: “Our train network does not have level access, and we heard Dame Tanni Grey-Thompson from the other place make this plea back in the summer, absolutely outrageous what she was put through. “But I was absolutely shocked to find, when I had a presentation of the TransPennine route upgrade, that the rolling stock yet to be commissioned is not going to provide that level access. “It’s absolute nonsense, it’s not even in the design of that procurement, so we must do better than this.”Donald Trump says he urged Gretzky to run for prime minister in Christmas visit

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Lawyers for embattled NH Supreme Court justice argue AG has a conflict of interest

Precious few garments have been made of spider silk. In 2012, a cape and shawl made from natural spider silk were displayed at the Victoria and Albert Museum, where visitors learned that the garments were the result of a unique project that spanned eight years and involved the harvesting of silk from 1.2 million spiders. In 2019, a rather less painstaking project utilized fibroin, the protein found in natural spider silk, to fabricate an outerwear jacket, North Face’s Moon Parka. Starting with fibroin meant that silk could be sourced from genetically modified bacteria, which are easier to work with than spiders. Nonetheless, the Moon Parka, which takes its name from the word moonshot, was never meant to be mass produced. It was available by lottery for just a limited time. Museum pieces and moonshots are hardly synonymous with “mass production.” Is there another way to generate spider silk–based textiles, one that has more commercial potential? Yes, according to Kraig Biocraft Laboratories, which uses transgenic silkworms to produce lines of recombinant spider silk. The company plans to produce up to 10 metric tons of spider silk in 2025. Production of actual spider silk lines on this scale would allow textile manufacturers to test the silk on their own equipment. It’s not just textiles that may benefit. Recombinant spider silk’s tensile strength, weight, and durability make it attractive for myriad applications, including tissue scaffolds and sutures in the biomedical field, as well as textiles and ballistic materials. “In a silkworm, there are several proteins that are produced in the silk glands,” Kim Thompson, founder and CEO of Kraig Biocraft Laboratories, tells . “One of those—a heavy chain fibroin—contributes roughly 96–98% of the molecular weight of the fiber.” Replacing the gene responsible for producing that protein with its counterpart in the spider results in recombinant spider silk. Kraig Biocraft produces spider silk using hybrid silkworms. As Thompson explains, hybrids of the two parental strains are more vigorous and produce better shaped cocoons. That vigor is passed down to subsequent generations. Kraig Biocraft’s approach appears to be unique in the spider silk industry. Other companies use vat fermentation to produce proteins that must be extracted, purified, and transformed into threads, adding steps and costs to the overall process. Spider silk’s high strength and light weight have attracted the interest of the U.S. Department of Defense. Dragline spider silk (which spiders use for the radial lines of their webs) requires 120,000–160,000 J/kg to break, whereas Kevlar requires 30,000–50,000 J/kg and steel requires 2,000–6,000 J/kg. Dragline spider silk weighs 1.18 and 1.36 g/cm , whereas Kevlar weighs 1.44 and steel weighs 7.84. Because spider silk combines strength, biocompatibility, and elasticity, it could be useful in tissue matrices and sutures. Dragline silk can increase its length by 27%, and flag silk (which spiders use for the spiral lines of their webs) can increase its length by 270%. Spider silk—or rather the technology behind it—could also be of interest to biopharmaceutical companies. For example, transgenic silkworms could serve as expression and production platforms for proteins other than spider silk proteins. Still, for Kraig Biocraft, the most immediate applications are in materials science. “We haven’t branched out into other areas that require more regulatory approval yet,” Thompson says. Thompson first approached the challenge of producing spider silk about 20 years ago. “I was looking at all the companies involved in that space,” he recalls. “The leader, Nexia Biotechnologies, was producing spider silk proteins in the milk of dairy goats.” “I thought that Nexia had misdiagnosed the problem and that it was about to hit a wall,” Thomson continues. Nexia’s method not only had difficulty with the mechanical challenges of transforming the proteins into fibers, but it was also extremely expensive. Thompson thought it would be better to create a cohesive fiber with the desired mechanical characteristics, than to create spider silk protein. He even suggested to Nexia that its scientists should use genetically engineered silkworms to produce fibers rather than using dairy goats to produce proteins. Nexia, however, preferred its approach, which yielded small proteins that were too weak to be spun into fiber. It declared bankruptcy in 2009. The University of Wyoming (UW), which held the rights to the genetic sequences Nexia has used to produce spider silk protein, granted Thompson exclusive rights to those sequences. “UW’s chief scientist, who had worked with Nexia, listed five reasons why it was scientifically impossible for these sequences to work in silkworms,” Thompson says. What that scientist may not have considered was that Thompson, working with molecular geneticist Malcolm J. Fraser, PhD, who then headed a laboratory at the University of Notre Dame, had a way to insert those sequences into silkworms. Fraser had co-developed the piggyback transposon, which “at the time was the only way to genetically engineer silkworms,” Thompson notes. Nonetheless, objections raised by the UW scientist reemerged every time Thompson approached a venture capital company for financing. Only by demonstrating dogged persistence did Thompson finally secure Kraig Biocraft the funding it needed to develop spider silk suitable for use by textile mills. Today, the company looks forward to starting commercial-scale production. “Our next inflection point is to produce the first metric ton of spider silk,” Thompson says. He adds that he is in discussions with “a number of significant players” to test Kraig’s recombinant spider silk on their machinery. The limiting factor, until now, has been an insufficient supply of product. “It’s hard to run a test when the world supply of spider silk has been measured in tens of kilograms,” he points out. To overcome supply problems, Kraig Biocraft plans to make good use of its new manufacturing site. “We have a backlog of order for prototype materials so they can make a test run,” Thompson says. According to Kraig Biocraft’s website, a kilogram of recombinant spider silk costs less than $300 to produce—about one tenth the cost of the protein alone using vat fermentation production methods. “To my knowledge, there are only three other companies involved in making spider silk: AMSilk, Bolt Threads, and Spiber,” Thompson says. Each uses vat fermentation to make the spider silk proteins, which he says significantly increases the costs. Thompson envisions a future of composite fibers in which spider silk is mixed with other textiles: “A lot of work continues to be done in that area, and it is accelerating.” He also points out that there are thousands of markets and technical applications for the advanced materials that are possible using recombinant spider silk: “We’re interested in capturing as much market share as we can, and we’re looking at new and expanded mechanical properties.” In the very near future, recombinant spider silk may be found in a range of products, from tissue scaffolds and sutures to performance fabrics. In that world, capes or expedition jackets made of spider silk won’t be rarities. They’ll be off-the-shelf articles. 2723 S State St, Ste 150, Ann Arbor, MI 48104 (734) 619-8066 Kim Thompson, Founder and CEO 20 Recombinant spider silk–based fibers from genetically engineered silk worms.

Amazon.com, Inc. (NASDAQ:AMZN) Shares Acquired by Pursue Wealth Partners LLCHyderabad: 3 held after woman dies at Allu Arjun’s Pushpa 2 premiere

What Snoop wants: Arizona Bowl gives NIL opportunities to players for Colorado State, Miami (Ohio)None