SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Dec 8, 2024-- Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), announced today data from a five-year follow-up of the pivotal Phase III POLARIX study evaluating Polivy ® (polatuzumab vedotin-piiq) in combination with Rituxan ® (rituximab), cyclophosphamide, doxorubicin and prednisone (R-CHP) in people with untreated diffuse large B-cell lymphoma (DLBCL). Data were presented in an oral session at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, December 7-10, 2024 in San Diego, California. This latest analysis conducted after a median follow-up of 60.9 months, includes descriptive data on primary and secondary endpoints, as well as safety results. “POLARIX was the first trial to elevate treatment standards for frontline diffuse large B-cell lymphoma in 20 years and we are additionally encouraged by the five-year follow-up results,” said Levi Garraway, M.D., Ph.D., Genentech’s chief medical officer and head of Global Product Development. “More than 38,000 people worldwide have been treated with Polivy in combination with R-CHP and these data continue to underscore its potential to improve outcomes for people diagnosed with this aggressive lymphoma.” Follow-up exploratory analysis after five-years indicated a positive trend in overall survival (OS) in the intent-to-treat (ITT) population in favor of Polivy in combination with R-CHP compared to Rituxan plus cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). Results showed a trend in reduction in the risk of death (HR 0.85; 95% CI: 0.63–1.15) for people with previously untreated DLBCL with the Polivy combination, an improvement on the three-year follow-up data (HR 0.94; 95% CI: 0.67–1.33). The five-year analysis of POLARIX indicates that the full difference in OS between treatment arms has yet to be observed and an additional two years of follow-up will continue. “Diffuse large B-cell lymphoma is a notoriously challenging cancer to treat, however, Polivy in combination with R-CHP has shown to be a critical advance for patients by helping to reduce relapse and disease progression,” said Gilles Salles, M.D., Ph.D., chief of Lymphoma Service, Division of Hematological Malignancies, Memorial Sloan Kettering Cancer Center, New York. “The survival trend seen in this follow-up analysis reinforces the potential impact of frontline treatment with Polivy in combination with R-CHP and its role as a standard of care therapy.” In addition to the positive trend in OS, an observational analysis suggested nearly 25% fewer follow-up treatments such as radiation, systemic chemotherapy and CAR-T cell therapy were needed in patients receiving Polivy in combination with R-CHP compared to those treated with R-CHOP (38.3% versus 61.7%). At five years of follow-up, benefits in progression-free survival and disease-free survival with Polivy in combination with R-CHP were maintained, consistent with the three-year follow-up data, reinforcing the potential of Polivy in combination with R-CHP to provide durable and lasting remissions. The latest follow-up data also showed a numerical reduction in death related to patients’ lymphoma in those treated with Polivy in combination with R-CHP compared to those treated with R-CHOP (9.0% versus 11.4%). The safety profile remains consistent with the known profiles of the individual study medicines with no new safety signals observed, reinforcing the positive benefit-risk profile of this Polivy combination. Results from an expanded cohort of 1,000 patients including global and Chinese patients demonstrated comparability to the global ITT population. Polivy in combination with R-CHP is currently approved for the treatment of first-line (1L) DLBCL in more than 90 countries worldwide including the U.S., countries throughout the EU, the U.K., Japan, Canada and China. Genentech continues to work with health authorities around the world to bring this treatment regimen to even more patients. Genentech aims to offer various treatment options for DLBCL that meet the diverse needs of patients and healthcare systems. In an effort to elevate treatment standards even further, Genentech is exploring Polivy in combination with other molecules, including its bispecific antibodies. Studies include the Phase III SUNMO trial evaluating the efficacy and safety of subcutaneously administered Lunsumio ® (mosunetuzumab-axgb) in combination with intravenous (IV) Polivy versus IV Rituxan plus gemcitabine and oxaliplatin (R-GemOx) in second-line or later DLBCL, and the Phase III SKYGLO trial investigating the efficacy of Polivy in combination with R-CHP and Columvi ® (glofitamab-gxbm) versus Polivy in combination with R-CHP in 1L DLBCL. About the POLARIX Study POLARIX [ NCT03274492 ] is an international Phase III, randomized, double-blind, placebo-controlled study evaluating the efficacy, safety and pharmacokinetics of Polivy ® (polatuzumab vedotin-piiq) plus Rituxan ® (rituximab), cyclophosphamide, doxorubicin and prednisone (R-CHP) versus Rituxan, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) in people with previously untreated diffuse large B-cell lymphoma (DLBCL). Eight-hundred and seventy-nine patients were randomized 1:1 to receive either Polivy plus R-CHP plus a vincristine placebo for six cycles, followed by Rituxan for two cycles; or R-CHOP plus a Polivy placebo for six cycles, followed by two cycles of Rituxan. The primary outcome measure is progression-free survival as assessed by the investigator using the Lugano Response Criteria for malignant lymphoma. POLARIX is being conducted in collaboration with The Lymphoma Study Association (LYSA) and The Lymphoma Academic Research Organisation (LYSARC). About Diffuse Large B-Cell Lymphoma Diffuse large B-cell lymphoma (DLBCL) is an aggressive (fast-growing) blood cancer and is the most common form of non-Hodgkin’s lymphoma (NHL) in the U.S. While many people with DLBCL are responsive to treatment, the majority of those who relapse or are refractory to subsequent treatments have poor outcomes. DLBCL not otherwise specified is the most common category of large B-cell lymphoma (LBCL) and accounts for about 80% or more of cases. It applies to cases that do not fall into any specific disease subgroups of LBCL. About Polivy ® (polatuzumab vedotin-piiq) Polivy is a first-in-class anti-CD79b antibody-drug conjugate (ADC). The CD79b protein is expressed specifically in the majority of B cells, an immune cell impacted in some types of non-Hodgkin’s lymphoma (NHL), making it a promising target for the development of new therapies. Polivy binds to cancer cells such as CD79b and destroys these B cells through the delivery of an anti-cancer agent, which is thought to minimize the effects on normal cells. Polivy is being developed by Genentech using Pfizer ADC technology and is currently being investigated for the treatment of several types of NHL. Polivy U.S. Indication Polivy is a prescription medicine used with other medicines (a rituximab product, cyclophosphamide, doxorubicin, and prednisone) as a first treatment for adults who have moderate to high risk diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS) or high-grade B-cell lymphoma (HGBL). Polivy is a prescription medicine used with other medicines, bendamustine and a rituximab product, to treat DLBCL in adults who have progressed after at least 2 prior therapies. Important Safety Information Possible serious side effects Everyone reacts differently to Polivy therapy, so it’s important to know what the side effects are. Some people who have been treated with Polivy have experienced serious to fatal side effects. Your doctor may stop or adjust your treatment if any serious side effects occur. Be sure to contact your healthcare team if there are any signs of these side effects. Side effects seen most often The most common side effects during treatment were Polivy may lower your red or white blood cell counts and increase uric acid levels. Polivy may not be for everyone. Talk to your doctor if you are These may not be all the side effects. Talk to your healthcare provider for more information about the benefits and risks of Polivy treatment. You may report side effects to the FDA at (800) FDA-1088 or http://www.fda.gov/medwatch . You may also report side effects to Genentech at (888) 835-2555. Please see the full Prescribing Information and visit https://www.Polivy.com for additional Important Safety Information. About Lunsumio ® (mosunetuzumab-axgb) Lunsumio is a first-in-class CD20xCD3 T-cell engaging bispecific antibody designed to target CD20 on the surface of B cells and CD3 on the surface of T cells. This dual targeting activates and redirects a patient’s existing T cells to engage and eliminate target B cells by releasing cytotoxic proteins into the B cells. A robust clinical development program for Lunsumio is ongoing, investigating the molecule as a monotherapy and in combination with other medicines, for the treatment of people with B-cell non-Hodgkin’s lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma, and other blood cancers. Lunsumio U.S. Indication Lunsumio (mosunetuzumab-axgb) is a prescription medicine used to treat adults with follicular lymphoma whose cancer has come back or did not respond to previous treatment, and who have already received two or more treatments for their cancer. It is not known if Lunsumio is safe and effective in children. The conditional approval of Lunsumio is based on response rate. There are ongoing studies to establish how well the drug works. What is the most important information I should know about Lunsumio? Lunsumio may cause Cytokine Release Syndrome (CRS), a serious side effect that is common during treatment with Lunsumio and can also be severe or life-threatening. Get medical help right away if you develop any signs or symptoms of CRS at any time, including: Due to the risk of CRS, you will receive Lunsumio on a “step-up dosing schedule.” Your healthcare provider will check you for CRS during treatment with Lunsumio and may treat you in a hospital if you develop signs and symptoms of CRS. Your healthcare provider may temporarily stop or completely stop your treatment with Lunsumio, if you have severe side effects. What are the possible side effects of Lunsumio? Lunsumio may cause serious side effects, including: Your healthcare provider may temporarily stop or permanently stop treatment with Lunsumio if you develop severe side effects. The most common side effects of Lunsumio include: tiredness, rash, fever, and headache. The most common severe abnormal blood test results with Lunsumio include: decreased phosphate, increased glucose, and increased uric acid levels. Before receiving Lunsumio, tell your healthcare provider about all of your medical conditions, including if you: Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. What should I avoid while receiving Lunsumio? Do not drive, operate heavy machinery, or do other dangerous activities if you develop dizziness, confusion, tremors, sleepiness, or any other symptoms that impair consciousness until your signs and symptoms go away. These may be signs and symptoms of CRS or neurologic problems. These are not all the possible side effects of Lunsumio. Talk to your healthcare provider for more information about the benefits and risks of Lunsumio. You may report side effects to the FDA at (800) FDA-1088 or http://www.fda.gov/medwatch . You may also report side effects to Genentech at (888) 835-2555. Please see Important Safety Information, including Serious Side Effects, as well as the Lunsumio full Prescribing Information and Medication Guide or visit https://www.Lunsumio.com . About Columvi ® (glofitamab-gxbm) Columvi is a CD20xCD3 T-cell engaging bispecific antibody designed to target CD3 on the surface of T cells and CD20 on the surface of B cells. Columvi was designed with a novel 2:1 structural format. This T-cell engaging bispecific antibody is engineered to have one region that binds to CD3, a protein on T cells, a type of immune cell, and two regions that bind to CD20, a protein on B cells, which can be healthy or malignant. This dual-targeting brings the T cell in close proximity to the B cell, activating the release of cancer cell-killing proteins from the T cell. Columvi is part of Genentech’s broad and industry-leading CD20xCD3 T-cell-engaging bispecific antibody clinical development program that also includes Lunsumio ® (mosunetuzumab), which aims to provide tailored treatment options that suit the diverse needs, preferences, and experiences of people with blood cancers and healthcare systems. Genentech is investigating Columvi as a monotherapy and in combination with other medicines for the treatment of diffuse large B-cell lymphoma and mantle cell lymphoma. Columvi U.S. Indication Columvi (glofitamab-gxbm) is a prescription medicine to treat adults with certain types of diffuse large B-cell lymphoma (DLBCL) or large B-cell lymphoma (LBCL) that has come back (relapsed) or that did not respond to previous treatment (refractory), and who have received 2 or more prior treatments for their cancer. It is not known if Columvi is safe and effective in children. The conditional approval of Columvi is based on response rate and durability of response. There are ongoing studies to establish how well the drug works. What is the most important information I should know about Columvi? Columvi can cause Cytokine Release Syndrome (CRS), a serious side effect that is common during treatment with Columvi, and can also be serious and lead to death. Call your healthcare provider or get emergency medical help right away if you develop any signs or symptoms of CRS, including: Due to the risk of CRS, you will receive Columvi on a “step-up dosing schedule”. Your healthcare provider will monitor you for CRS during treatment with Columvi and may treat you in a hospital if you develop signs and symptoms of CRS. Your healthcare provider may temporarily stop or completely stop your treatment with Columvi if you have severe side effects. Carry the Columvi Patient Wallet Card with you at all times and show it to all of your healthcare providers. The Columvi Patient Wallet Card lists the signs and symptoms of CRS you should get emergency medical help for right away. What are the possible side effects of Columvi? Columvi may cause serious side effects, including: The most common side effects of Columvi include: CRS, muscle and bone pain, rash, and tiredness. The most common severe abnormal lab test results with Columvi include: decreased white blood cells, decreased phosphate (an electrolyte), increased uric acid levels, and decreased fibrinogen (a protein that helps with blood clotting). Your healthcare provider may temporarily stop or completely stop treatment with Columvi if you develop certain side effects. Before receiving Columvi, tell your healthcare provider about all of your medical conditions, including if you: Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. What should I avoid while receiving Columvi? Do not drive, operate heavy machinery, or do other dangerous activities if you develop dizziness, confusion, shaking (tremors), sleepiness, or any other symptoms that impair consciousness until your signs and symptoms go away. These may be signs and symptoms of neurologic problems. These are not all the possible side effects of Columvi. Talk to your health care provider for more information about the benefits and risks of Columvi. You may report side effects to the FDA at (800) FDA-1088 or http://www.fda.gov/medwatch . You may also report side effects to Genentech at (888) 835-2555. Please see Important Safety Information, including Serious Side Effects , as well as the Columvi full Prescribing Information and Medication Guide or visit https://www.Columvi.com About Genentech in Hematology For more than 20 years, Genentech has been developing medicines with the goal to redefine treatment in hematology. Today, we’re investing more than ever in our effort to bring innovative treatment options to people with diseases of the blood. For more information visit http://www.gene.com/hematology . About Genentech Founded more than 40 years ago, Genentech is a leading biotechnology company that discovers, develops, manufactures and commercializes medicines to treat patients with serious and life-threatening medical conditions. The company, a member of the Roche Group, has headquarters in South San Francisco, California. For additional information about the company, please visit http://www.gene.com . Dr. Salles has financial interests related to Roche and Genentech. View source version on businesswire.com : https://www.businesswire.com/news/home/20241208818007/en/ CONTACT: Media Contact: Kristen Ingram, (650) 467-6800Advocacy Contact: Catherine Creme Henry, (202) 258-8228Investor Contacts: Loren Kalm, (650) 225-3217 Bruno Eschli, 011 41 61 687 5284 KEYWORD: CALIFORNIA UNITED STATES NORTH AMERICA INDUSTRY KEYWORD: BIOTECHNOLOGY HEALTH PHARMACEUTICAL CLINICAL TRIALS ONCOLOGY SOURCE: Genentech Copyright Business Wire 2024. PUB: 12/08/2024 12:30 PM/DISC: 12/08/2024 12:30 PM http://www.businesswire.com/news/home/20241208818007/enskygaming 。

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After-hours movers: HP Inc., Dell Technologies, Workday and moreWeek 12 of the NFL season kicked off Thursday with the Cleveland Browns winning a snowy battle against the Pittsburgh Steelers . Sunday started with a handful of thrillers. The Dallas Cowboys snapped their five-game skid, beating the Washington Commanders , and the Tennessee Titans upset the Houston Texans . The Minnesota Vikings earned an overtime win against the Chicago Bears , and the Kansas City Chiefs narrowly beat the Carolina Panthers . Our NFL Nation reporters reacted to all the action, answering lingering questions coming out of each game and detailing everything else you need to know for every team. Let's get to it. Jump to: PIT-CLE | TB-NYG | DET-IND KC-CAR | NE-MIA | TEN-HOU DAL-WSH | MIN-CHI Minnesota 30, Chicago 27 Vikings How did the Vikings let this game get to overtime? Simply put, weird things happen to the Vikings at Soldier Field. The Vikings were up by 11 points with 22 seconds remaining. Although their defense allowed Bears quarterback Caleb Williams to run all over it in the fourth quarter, the real issue was tight end Johnny Mundt letting an onside kick hit him in the foot. That allowed the Bears to recover the kick long before it went the required 10 yards. If it had not been for that fluke bounce, the conversation would have been much different. Most surprising performance: No. 2 receiver Jordan Addison had a huge day, catching seven passes for a career-high 162 yards and a touchdown. The Vikings finally made an opponent pay for the attention it was paying to Justin Jefferson , but he managed only seven receiving yards in regulation. That would have been a career low before Jefferson caught a 20-yard pass in overtime. What we learned about the QB today: Quarterback Sam Darnold is tough, and he might have had his best stretch as an NFL player in overtime. He left Sunday's game for two plays in the fourth quarter because of what appeared to be an ankle injury. But he returned and completed all six of his pass attempts in overtime to salvage the game. -- Kevin Seifert Next game: vs. Cardinals (Sunday, 1 p.m. ET) Bears Has Caleb Williams been more efficient with Thomas Brown as offensive coordinator? Williams has averaged 2.42 seconds on passes in Brown's two games as interim OC, which marks his quickest throws this season. That helped him go 9-of-12 for 128 yards and two touchdowns against the blitz, which is his first multi-TD game versus the blitz this season. He was 5-of-12 for 141 yards on passes with at least 15 air yards, which was his season-best. Williams also showed an ability to evade pressure and make difficult throws on the run, highlighted by throws to Keenan Allen and D'Andre Swift on Chicago's first touchdown drive. Most surprising performance: Allen was a late addition to the injury report Friday after rolling his ankle in practice, but he turned in a season-high, team-best nine catches for 86 yards and a touchdown. He ignited the Bears' dormant deep passing game when he hauled in a 40-yard reception from Williams that set up Chicago's lone touchdown in the first quarter. This was Allen's third game with double-digit targets. Eye-popping stat: After his blocked game-winner against Green Bay, Cairo Santos ' first field goal attempt of the afternoon was blocked by the Vikings. His three blocked field goals are the most in the NFL this season and Chicago's most in a season since 2012 (also three). He converted on two other attempts, including a 48-yarder to send the game into overtime. -- Courtney Cronin Next game: at Lions (Thursday, 12:30 p.m. ET) Dallas 34, Washington 26 Cowboys How the heck did the Cowboys pull that off? The Cowboys entered the game with more than $100 million in salary cap space on injured reserve in Dak Prescott , DeMarcus Lawrence , Zack Martin , Trevon Diggs and Brandin Cooks . Their best offensive lineman, Tyler Smith (ankle), was also ruled out Sunday. They overcame two missed field goals, a deflected punt, a penalty on a kickoff and iced the game on a pair of kickoff returns by KaVontae Turpin (99 yards) and Juanyeh Thomas (43 yards) after Washington nearly pulled off its second miracle of the season. What we learned about the QB today: Cooper Rush is steady, and that's what teams need from their backup quarterback. Against the Commanders, Rush completed a season-high 78.5% of his passes and avoided big mistakes. His previous best as a starter was 67.7% in a 2022 win against the Giants. He threw two touchdown passes in the second half and looked like the quarterback who went 4-1 as Dak Prescott's replacement in 2022. Early prediction for next week: When the Cowboys host the Giants, don't expect an uptick in the quality of football after the Giants lost 30-7 to the Buccaneers. This will be just the fourth time in the Super Bowl era that both teams are under .500 when playing on Thanksgiving. At least the Cowboys enter the game with a win. -- Todd Archer Next game: vs. Giants (Thursday, 4:30 p.m. ET) Commanders What's wrong with the offense? Washington's offense powered its 7-2 start. Now it's responsible for its past two losses. Dallas' defense entered the game ranked 29th in scoring and 23rd in yards, but Washington managed only 319 yards, surpassing 300 for the first time in three games. The offensive line is banged up, and in the past three games, its running backs have averaged 3.2 yards per carry and gained 181 yards combined. What we learned about the QB today: It hasn't been good. The pass game lacked any rhythm, and quarterback Jayden Daniels averaged just 3.9 yards per attempt until he had to throw downfield to play catch-up late in the game. Daniels was considered an MVP contender early in the season. Now they just need to get him back to being the presumptive Offensive Rookie of the Year. Biggest hole in the game plan: The kicking game. Austin Seibert missed two extra points and a 51-yard field goal. Entering the game, Seibert had made 25 of 28 field goals and all 22 extra-point attempts. However, he had missed the past two weeks with a hip injury and was bad Sunday. Tyler Ott 's low snaps and a 99-yard kick return by the Cowboys didn't help either. -- John Keim Next game: vs. Titans (Sunday, 1 p.m. ET) Tennessee 32, Houston 27 Titans Is the Titans' offense starting to wake up? The Titans scored 30 points for the second time this season. Before reaching that threshold against the Dolphins in Week 4, Tennessee had not done it since Jan 2, 2022. Nick Westbrook-Ikhine continued his hot play with his sixth touchdown over the previous six games. The suddenly explosive passing game produced three plays of 30 yards or more, matching last week's output against the Vikings. Eye-popping stat: Will Levis absorbed seven sacks in the first half, becoming the first QB to be sacked at least seven times in multiple halves of a season since Randall Cunningham with the Eagles in 1986. Levis was also sacked seven times by the Packers in the second half of a Week 3 loss. What we learned about the QB today: Levis continues to be late on throws or avoid making them. At least three of Houston's eight sacks could have been avoided if he saw receivers coming open. His predetermined read kept him from seeing Texans safety Jimmie Ward in the passing lane, leading to a pick-six. But Levis showed resilience, connecting with Chig Okonkwo for a 70-yard touchdown that held up as the game-winner. -- Turron Davenport Next game: at Commanders (Sunday, 1 p.m. ET) Texans Will the Texans' defensive struggles become a trend? The Texans allowed quarterback Will Levis to go 18-of-23 for 278 passing yards and two touchdowns. In December, Houston faces the Dolphins, Chiefs and Ravens, whose offenses can score in bunches. Those issues must get fixed or the hopes of a deep playoff run won't materialize. Eye-popping stat: Ka'imi Fairbairn 's missed 28-yard field goal in the fourth quarter was unexpected. It moved NFL teams to 155-159 (97.5%) on field goals of 29 or fewer yards (98.0%) in 2024. Two of those misses are by Fairbairn. What we learned about the QB today: C.J. Stroud 's performance was a mixed bag. He threw multiple touchdown passes for the first time since Oct. 13, but he also threw multiple interceptions for the second time in three weeks and was sacked four times. Houston's line has allowed 17 sacks in its last four games. -- DJ Bien-Aime Next game: at Jaguars (Sunday, 1 p.m. ET) Miami 34, New England 15 Dolphins Can Miami's offense continue to be efficient at Green Bay on Thanksgiving? The temperatures for the Dolphins' game against the Packers are expected to drop below freezing -- which has historically been the Dolphins' kryptonite. But with a convicted emphasis on high-efficiency passes and ball control this season, Miami appears to be better equipped to play in frigid temperatures than it was in either of the past two seasons. If it can overcome the weather, Thursday night presents an intriguing matchup for Miami against a Packers defense that ranks 22nd in defensive expected points added since Week 8. What we learned about the QB today: Quarterback Tua Tagovailoa has matured as a passer and that was on full display Sunday with a four-touchdown performance. He completed 72.5% of his passes against the Patriots -- not far from his career-high 74% this season. It's clear he is less insistent on attempting deep passes and more willing to take what defenses give him. Early prediction for next week: Tight end Jonnu Smith will have another big game against the Packers. He has scored three touchdowns in his past two games and faces a Green Bay defense that's allowed the 13th-most yards to opposing tight ends this season (entering Sunday). Miami's intention to run the passing offense through Smith is no secret, but Green Bay is still more likely to shade coverage toward receivers Tyreek Hill and Jaylen Waddle . -- Marcel Louis-Jacques Next game: at Packers (Thursday, 8:20 p.m. ET) Patriots Was this no-show effort an outlier or a sign of things to come in the final five games? The Patriots had played competitively in four games since coach Jerod Mayo called the team out for " playing soft ," so this was a big step back. It was a poor reflection on Mayo and his staff, as well as the players. The Patriots return home to face the Colts on Sunday, then they have their bye week before finishing the season against the Cardinals, Bills, Chargers and Bills again. Mayo has said he hopes to be a team that no one wants to play coming down the homestretch. They hardly looked like that against Miami. Describe the game in two words: Undisciplined mess. The Patriots had nine penalties in the first half, six of which were pre-snap infractions -- four false starts, one offensive offside and one defensive neutral zone infraction. Before a team can beat an opponent, it has to not beat itself. Biggest hole in the game plan: Was there a game plan? The Dolphins ran circles around them, especially in a 24-0 second quarter, which was the largest margin in any NFL quarter this season. Tackling on defense was also shoddy. -- Mike Reiss Next game: vs. Colts (Sunday, 1 p.m. ET) Kansas City 30, Carolina 27 Chiefs What does the emergence of more receiver options mean for the rest of the Chiefs' season? The Chiefs can't have too many threats, so having another reliable receiver is a welcome development for them. It's unlikely their passing game will feature as many big plays as they envisioned before the start of the season, but the Chiefs showed against the Panthers they can be effective with mostly shorter gains. Wide receiver Hollywood Brown could return later in the season, which would give the Chiefs yet another threat. Eye-popping stat: Tight end Noah Gray had 11.9 yards of separation on his first touchdown, which is the most yards of separation on a Chiefs receiving touchdown in the past two seasons. He was wide open. Most surprising performance: The Chiefs' defense had more trouble with quarterback Bryce Young and the Carolina offense than expected. The Panthers entered the game averaging 281 yards (last in the league) and 17 points (30th). But the Chiefs failed to contain them. Carolina had 249 passing yards, allowing them to tie the game with less than two minutes left. -- Adam Teicher Next game: vs. Raiders (Friday, 3 p.m. ET) Chiefs Spencer Shrader sinks 31-yard game-winning field goal as time expires. Panthers Did Bryce Young earn the right to start the rest of the season? Coach Dave Canales has been careful not to name Young the starter each week until evaluating the film. No further need. The top pick of the 2023 draft had his best game, considering the opponent, and deserves to play out the season. He handled the blitz in particular like a seasoned pro. He was blitzed on 38% of dropbacks. He was 11 of 13 for a season-high 135 yards with a touchdown against five or more defenders. Describe the game in two words: Turning point? Despite the loss, Carolina went toe-to-toe with the two-time defending Super Bowl champions. This may have been a bigger confidence booster than the consecutive wins against the Saints and Giants entering the day. Young looked great. The defense created pressure (5 sacks). This team had an identity. Biggest hole in the game plan: Defending the Chiefs' second tight end, Noah Gray. He had four catches for 66 yards and two touchdowns, including a 35-yarder on the first series. The Panthers did a decent job on star Travis Kelce , but Gray made them pay throughout the afternoon. -- David Newton Next game: vs. Bucs (Sunday, 4:05 p.m. ET) Detroit 24, Indianapolis 6 Lions Are Jahmyr Gibbs and David Montgomery the NFL's top rushing duo? Nicknamed "Sonic & Knuckles," Gibbs and Montgomery combined for three rushing touchdowns against the Colts, becoming the first duo in NFL history with 10 rushing touchdowns each in consecutive seasons. Sunday's game also marked the 11th time the duo has each scored a touchdown in the same game -- including the playoffs -- which is the most such games by an RB duo in NFL history, per ESPN Research. At this point, it's not a question of whether they're the best in the league; the production speaks for itself. It's now time to decide their place in league history if they can keep it up. Biggest hole in the game plan: Defending the deep ball. Dealing with a groin injury , rookie cornerback Terrion Arnold was ruled out for Sunday's game and didn't travel with the team. His absence was felt. Detroit's defense allowed Colts quarterback Anthony Richardson to connect with Michael Pittman Jr . for a 30-yard pass and another 39-yard bomb to Alec Pierce . Most surprising performance: Lions wideout Tim Patrick . In Detroit's previous four games, Patrick logged five receptions for 38 yards, but he found a groove against the Colts. He grabbed four receptions for 55 yards, including a 27-yard catch at the end of the first quarter, which helped the Lions offense find an early rhythm. -- Eric Woodyard Next game: vs. Bears (Thursday, 12:30 p.m. ET) Colts Do the Colts still have a realistic shot at the postseason? The Colts entered the day in the eighth position among AFC playoff contenders and didn't help their case with a loss. After starting the day with a 34% shot at the playoffs, according to ESPN Analytics, the defeat lowered those chances to 27% independent of other outcomes. On the other hand, the Colts have one of the more favorable schedules down the stretch, with four of their five remaining opponents currently under .500. In any case, it will take significant work for them to reverse the damage done to their postseason hopes by losing four of their past five games. What we learned about the QB today: Sunday demonstrated that Anthony Richardson needs more help from his supporting cast. Indianapolis was flagged for a season-high eight offensive penalties, several of them proving to be crushing by negating big plays from the quarterback. Richardson also had some underwhelming performances from his pass targets, including a dropped touchdown by tight end Drew Ogletree . Eye-popping stat: This was the first loss in a game in which the Colts did not commit a turnover since a loss to the Raiders on Jan. 2, 2022. In the past five seasons, the Colts have 22 games in which they have avoided a turnover. They are now 19-3 in those contests. The Colts' six points Sunday is the fewest scored in any of those three losses. -- Stephen Holder Next game: at Patriots (Sunday, 1 p.m. ET) Tampa Bay 30, N.Y. Giants 7 Buccaneers Is this the jolt the Bucs needed to ignite a playoff push? Yes, as long as quarterback Baker Mayfield 's stinger isn't serious and these late-game fumbles stop. Getting franchise leading scorer Mike Evans back was huge. So was having both starting cornerbacks in Jamel Dean and Zyon McCollum , and the waiver wire pickup of safety Mike Edwards , who came in on third-down passing situations and then to relieve Jordan Whitehead after he had a pectoral injury in the fourth quarter. Only one of their remaining opponents -- the Chargers -- has a winning record. What we learned about the QB today: Mayfield still has some of that Oklahoma swag, or "spavalderia" if we're speaking Italian. Never mind the Bucs came into Sunday's game on a four-game losing streak. He hurdled Giants cornerback Cor'Dale Flott , did Giants quarterback Tommy DeVito 's signature celebration and sprinted downfield to deliver a block on Bucky Irving 's 56-yard run. Eye-popping stat: The Bucs had 11 different receiving targets catch passes, tied for their most in a game in franchise history. This was last done Week 16 of 2020, when Tom Brady threw for four touchdowns in a 47-7 win over the Lions, according to ESPN Research. -- Jenna Laine Next game: at Panthers (Sunday, 4:05 p.m. ET) Bucky Irving dances through the Giants defense for an impressive 56-yard gain for the Buccaneers. Giants How much did the release of Daniel Jones lead to this blowout loss? It's hard to imagine it wasn't a significant factor. The Giants benched their starting quarterback, saw him step in as a scout-team safety during a walk-through period at practice Thursday, and he was released by Friday. Players such as captain Dexter Lawrence II said publicly they thought Jones was still the team's best quarterback. Clearly, it had an effect. DeVito hardly provided the "spark" or energy that coach Brian Daboll thought it would while his team fell behind 23-0 by halftime. What we learned about the QB today: DeVito wasn't the answer. He went 3-of-5 passing for 31 yards with three sacks in the first half. He finished 21 of 31 passing for 189 yards. He was also sacked four times. Not that DeVito stood a chance. The Giants lost left tackle Jermaine Eluemunor on the opening drive. That put third-string left tackle Chris Hubbard into the game opposite Evan Neal for what was already the lowest-scoring offense in the NFL. Most surprising performance: A no-show by the Giants defense coming out of the bye week. Inexcusable. At points, Lawrence stood despondent, by himself, on the sideline. Perhaps it was because the defense barely sniffed Bucs quarterback Baker Mayfield during a sackless afternoon while allowing 400-plus yards of offense. -- Jordan Raanan Next game: at Cowboys (Thursday, 4:30 p.m. ET) Pittsburgh 24, Cleveland 19 Steelers Is this loss a wake up call for the Steelers offense? Don't be distracted by the first part of Russell Wilson 's stat line. Yes, the quarterback completed 21 of 28 attempts for 270 yards and a touchdown, but he was also sacked four times. And the offense had six empty possessions that ended either with a punt, turnover on downs or a turnover. Wilson had some moments of field-stretching brilliance, firing off three deep balls on third-down completions to Calvin Austin, Van Jefferson and George Pickens , but he also struggled against pressure. Winning like they did against the Ravens, with six Chris Boswell field goals, isn't sustainable. It wasn't against the Browns, and it won't be as the gauntlet of AFC North games continues. Describe the game in two words: Trap game. Hindsight is 20/20, but this had all the makings of a trap game. Though the Steelers said they didn't overlook the hapless Browns, they were clearly overpowered and outwitted by a motivated team playing with nothing to lose. Browns coach Kevin Stefanski took risks that paid off, while Steelers coach Mike Tomlin did the opposite. Eye-popping stat: Though they briefly erased their 12-point deficit, the Steelers are the only franchise that hasn't overcome a deficit of 12 or more points in the fourth quarter of a regular season game since 2000, per ESPN Research. -- Brooke Pryor Next game: at Bengals (Sunday, 1 p.m. ET) Browns Will the Browns play spoiler during the final stretch of the season? Thursday night's win over the Steelers marked the Browns' second upset victory over a divisional opponent, coming weeks after they stunned the Ravens. With four of its final six games coming against teams with winning records, Cleveland has the opportunity to play spoiler a few more times and a strong finish could raise optimism heading into the offseason with a roster that disappointed in the first half of the season. Describe the game in two words: No quit. Four days after giving up 21 points in the fourth quarter of a blowout loss to the Saints -- their seventh defeat in their previous eight games -- the Browns delivered a gritty victory at home against the division-leading Steelers. Most surprising performance: Browns offensive tackle Jack Conklin . The veteran lineman held outside linebacker T.J. Watt to just one pressure across 24 matchups. It was just the second game this season that Watt was held to one pressure. -- Daniel Oyefusi Next game: at Broncos (Monday, 8:15 p.m. ET)

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Chiefs' Patrick Mahomes leads game-winning Drive to save face against PanthersWeek 12 of the NFL season kicked off Thursday with the Cleveland Browns winning a snowy battle against the Pittsburgh Steelers . Sunday started with a handful of thrillers. The Dallas Cowboys snapped their five-game skid, beating the Washington Commanders , and the Tennessee Titans upset the Houston Texans . The Minnesota Vikings earned an overtime win against the Chicago Bears , and the Kansas City Chiefs narrowly beat the Carolina Panthers . Our NFL Nation reporters reacted to all the action, answering lingering questions coming out of each game and detailing everything else you need to know for every team. Let's get to it. Jump to: PIT-CLE | TB-NYG | DET-IND KC-CAR | NE-MIA | TEN-HOU DAL-WSH | MIN-CHI Minnesota 30, Chicago 27 Vikings How did the Vikings let this game get to overtime? Simply put, weird things happen to the Vikings at Soldier Field. The Vikings were up by 11 points with 22 seconds remaining. Although their defense allowed Bears quarterback Caleb Williams to run all over it in the fourth quarter, the real issue was tight end Johnny Mundt letting an onside kick hit him in the foot. That allowed the Bears to recover the kick long before it went the required 10 yards. If it had not been for that fluke bounce, the conversation would have been much different. Most surprising performance: No. 2 receiver Jordan Addison had a huge day, catching seven passes for a career-high 162 yards and a touchdown. The Vikings finally made an opponent pay for the attention it was paying to Justin Jefferson , but he managed only seven receiving yards in regulation. That would have been a career low before Jefferson caught a 20-yard pass in overtime. What we learned about the QB today: Quarterback Sam Darnold is tough, and he might have had his best stretch as an NFL player in overtime. He left Sunday's game for two plays in the fourth quarter because of what appeared to be an ankle injury. But he returned and completed all six of his pass attempts in overtime to salvage the game. -- Kevin Seifert Next game: vs. Cardinals (Sunday, 1 p.m. ET) Bears Has Caleb Williams been more efficient with Thomas Brown as offensive coordinator? Williams has averaged 2.42 seconds on passes in Brown's two games as interim OC, which marks his quickest throws this season. That helped him go 9-of-12 for 128 yards and two touchdowns against the blitz, which is his first multi-TD game versus the blitz this season. He was 5-of-12 for 141 yards on passes with at least 15 air yards, which was his season-best. Williams also showed an ability to evade pressure and make difficult throws on the run, highlighted by throws to Keenan Allen and D'Andre Swift on Chicago's first touchdown drive. Most surprising performance: Allen was a late addition to the injury report Friday after rolling his ankle in practice, but he turned in a season-high, team-best nine catches for 86 yards and a touchdown. He ignited the Bears' dormant deep passing game when he hauled in a 40-yard reception from Williams that set up Chicago's lone touchdown in the first quarter. This was Allen's third game with double-digit targets. Eye-popping stat: After his blocked game-winner against Green Bay, Cairo Santos ' first field goal attempt of the afternoon was blocked by the Vikings. His three blocked field goals are the most in the NFL this season and Chicago's most in a season since 2012 (also three). He converted on two other attempts, including a 48-yarder to send the game into overtime. -- Courtney Cronin Next game: at Lions (Thursday, 12:30 p.m. ET) Dallas 34, Washington 26 Cowboys How the heck did the Cowboys pull that off? The Cowboys entered the game with more than $100 million in salary cap space on injured reserve in Dak Prescott , DeMarcus Lawrence , Zack Martin , Trevon Diggs and Brandin Cooks . Their best offensive lineman, Tyler Smith (ankle), was also ruled out Sunday. They overcame two missed field goals, a deflected punt, a penalty on a kickoff and iced the game on a pair of kickoff returns by KaVontae Turpin (99 yards) and Juanyeh Thomas (43 yards) after Washington nearly pulled off its second miracle of the season. What we learned about the QB today: Cooper Rush is steady, and that's what teams need from their backup quarterback. Against the Commanders, Rush completed a season-high 78.5% of his passes and avoided big mistakes. His previous best as a starter was 67.7% in a 2022 win against the Giants. He threw two touchdown passes in the second half and looked like the quarterback who went 4-1 as Dak Prescott's replacement in 2022. Early prediction for next week: When the Cowboys host the Giants, don't expect an uptick in the quality of football after the Giants lost 30-7 to the Buccaneers. This will be just the fourth time in the Super Bowl era that both teams are under .500 when playing on Thanksgiving. At least the Cowboys enter the game with a win. -- Todd Archer Next game: vs. Giants (Thursday, 4:30 p.m. ET) Commanders What's wrong with the offense? Washington's offense powered its 7-2 start. Now it's responsible for its past two losses. Dallas' defense entered the game ranked 29th in scoring and 23rd in yards, but Washington managed only 319 yards, surpassing 300 for the first time in three games. The offensive line is banged up, and in the past three games, its running backs have averaged 3.2 yards per carry and gained 181 yards combined. What we learned about the QB today: It hasn't been good. The pass game lacked any rhythm, and quarterback Jayden Daniels averaged just 3.9 yards per attempt until he had to throw downfield to play catch-up late in the game. Daniels was considered an MVP contender early in the season. Now they just need to get him back to being the presumptive Offensive Rookie of the Year. Biggest hole in the game plan: The kicking game. Austin Seibert missed two extra points and a 51-yard field goal. Entering the game, Seibert had made 25 of 28 field goals and all 22 extra-point attempts. However, he had missed the past two weeks with a hip injury and was bad Sunday. Tyler Ott 's low snaps and a 99-yard kick return by the Cowboys didn't help either. -- John Keim Next game: vs. Titans (Sunday, 1 p.m. ET) Tennessee 32, Houston 27 Titans Is the Titans' offense starting to wake up? The Titans scored 30 points for the second time this season. Before reaching that threshold against the Dolphins in Week 4, Tennessee had not done it since Jan 2, 2022. Nick Westbrook-Ikhine continued his hot play with his sixth touchdown over the previous six games. The suddenly explosive passing game produced three plays of 30 yards or more, matching last week's output against the Vikings. Eye-popping stat: Will Levis absorbed seven sacks in the first half, becoming the first QB to be sacked at least seven times in multiple halves of a season since Randall Cunningham with the Eagles in 1986. Levis was also sacked seven times by the Packers in the second half of a Week 3 loss. What we learned about the QB today: Levis continues to be late on throws or avoid making them. At least three of Houston's eight sacks could have been avoided if he saw receivers coming open. His predetermined read kept him from seeing Texans safety Jimmie Ward in the passing lane, leading to a pick-six. But Levis showed resilience, connecting with Chig Okonkwo for a 70-yard touchdown that held up as the game-winner. -- Turron Davenport Next game: at Commanders (Sunday, 1 p.m. ET) Texans Will the Texans' defensive struggles become a trend? The Texans allowed quarterback Will Levis to go 18-of-23 for 278 passing yards and two touchdowns. In December, Houston faces the Dolphins, Chiefs and Ravens, whose offenses can score in bunches. Those issues must get fixed or the hopes of a deep playoff run won't materialize. Eye-popping stat: Ka'imi Fairbairn 's missed 28-yard field goal in the fourth quarter was unexpected. It moved NFL teams to 155-159 (97.5%) on field goals of 29 or fewer yards (98.0%) in 2024. Two of those misses are by Fairbairn. What we learned about the QB today: C.J. Stroud 's performance was a mixed bag. He threw multiple touchdown passes for the first time since Oct. 13, but he also threw multiple interceptions for the second time in three weeks and was sacked four times. Houston's line has allowed 17 sacks in its last four games. -- DJ Bien-Aime Next game: at Jaguars (Sunday, 1 p.m. ET) Miami 34, New England 15 Dolphins Can Miami's offense continue to be efficient at Green Bay on Thanksgiving? The temperatures for the Dolphins' game against the Packers are expected to drop below freezing -- which has historically been the Dolphins' kryptonite. But with a convicted emphasis on high-efficiency passes and ball control this season, Miami appears to be better equipped to play in frigid temperatures than it was in either of the past two seasons. If it can overcome the weather, Thursday night presents an intriguing matchup for Miami against a Packers defense that ranks 22nd in defensive expected points added since Week 8. What we learned about the QB today: Quarterback Tua Tagovailoa has matured as a passer and that was on full display Sunday with a four-touchdown performance. He completed 72.5% of his passes against the Patriots -- not far from his career-high 74% this season. It's clear he is less insistent on attempting deep passes and more willing to take what defenses give him. Early prediction for next week: Tight end Jonnu Smith will have another big game against the Packers. He has scored three touchdowns in his past two games and faces a Green Bay defense that's allowed the 13th-most yards to opposing tight ends this season (entering Sunday). Miami's intention to run the passing offense through Smith is no secret, but Green Bay is still more likely to shade coverage toward receivers Tyreek Hill and Jaylen Waddle . -- Marcel Louis-Jacques Next game: at Packers (Thursday, 8:20 p.m. ET) Patriots Was this no-show effort an outlier or a sign of things to come in the final five games? The Patriots had played competitively in four games since coach Jerod Mayo called the team out for " playing soft ," so this was a big step back. It was a poor reflection on Mayo and his staff, as well as the players. The Patriots return home to face the Colts on Sunday, then they have their bye week before finishing the season against the Cardinals, Bills, Chargers and Bills again. Mayo has said he hopes to be a team that no one wants to play coming down the homestretch. They hardly looked like that against Miami. Describe the game in two words: Undisciplined mess. The Patriots had nine penalties in the first half, six of which were pre-snap infractions -- four false starts, one offensive offside and one defensive neutral zone infraction. Before a team can beat an opponent, it has to not beat itself. Biggest hole in the game plan: Was there a game plan? The Dolphins ran circles around them, especially in a 24-0 second quarter, which was the largest margin in any NFL quarter this season. Tackling on defense was also shoddy. -- Mike Reiss Next game: vs. Colts (Sunday, 1 p.m. ET) Kansas City 30, Carolina 27 Chiefs What does the emergence of more receiver options mean for the rest of the Chiefs' season? The Chiefs can't have too many threats, so having another reliable receiver is a welcome development for them. It's unlikely their passing game will feature as many big plays as they envisioned before the start of the season, but the Chiefs showed against the Panthers they can be effective with mostly shorter gains. Wide receiver Hollywood Brown could return later in the season, which would give the Chiefs yet another threat. Eye-popping stat: Tight end Noah Gray had 11.9 yards of separation on his first touchdown, which is the most yards of separation on a Chiefs receiving touchdown in the past two seasons. He was wide open. Most surprising performance: The Chiefs' defense had more trouble with quarterback Bryce Young and the Carolina offense than expected. The Panthers entered the game averaging 281 yards (last in the league) and 17 points (30th). But the Chiefs failed to contain them. Carolina had 249 passing yards, allowing them to tie the game with less than two minutes left. -- Adam Teicher Next game: vs. Raiders (Friday, 3 p.m. ET) Chiefs Spencer Shrader sinks 31-yard game-winning field goal as time expires. Panthers Did Bryce Young earn the right to start the rest of the season? Coach Dave Canales has been careful not to name Young the starter each week until evaluating the film. No further need. The top pick of the 2023 draft had his best game, considering the opponent, and deserves to play out the season. He handled the blitz in particular like a seasoned pro. He was blitzed on 38% of dropbacks. He was 11 of 13 for a season-high 135 yards with a touchdown against five or more defenders. Describe the game in two words: Turning point? Despite the loss, Carolina went toe-to-toe with the two-time defending Super Bowl champions. This may have been a bigger confidence booster than the consecutive wins against the Saints and Giants entering the day. Young looked great. The defense created pressure (5 sacks). This team had an identity. Biggest hole in the game plan: Defending the Chiefs' second tight end, Noah Gray. He had four catches for 66 yards and two touchdowns, including a 35-yarder on the first series. The Panthers did a decent job on star Travis Kelce , but Gray made them pay throughout the afternoon. -- David Newton Next game: vs. Bucs (Sunday, 4:05 p.m. ET) Detroit 24, Indianapolis 6 Lions Are Jahmyr Gibbs and David Montgomery the NFL's top rushing duo? Nicknamed "Sonic & Knuckles," Gibbs and Montgomery combined for three rushing touchdowns against the Colts, becoming the first duo in NFL history with 10 rushing touchdowns each in consecutive seasons. Sunday's game also marked the 11th time the duo has each scored a touchdown in the same game -- including the playoffs -- which is the most such games by an RB duo in NFL history, per ESPN Research. At this point, it's not a question of whether they're the best in the league; the production speaks for itself. It's now time to decide their place in league history if they can keep it up. Biggest hole in the game plan: Defending the deep ball. Dealing with a groin injury , rookie cornerback Terrion Arnold was ruled out for Sunday's game and didn't travel with the team. His absence was felt. Detroit's defense allowed Colts quarterback Anthony Richardson to connect with Michael Pittman Jr . for a 30-yard pass and another 39-yard bomb to Alec Pierce . Most surprising performance: Lions wideout Tim Patrick . In Detroit's previous four games, Patrick logged five receptions for 38 yards, but he found a groove against the Colts. He grabbed four receptions for 55 yards, including a 27-yard catch at the end of the first quarter, which helped the Lions offense find an early rhythm. -- Eric Woodyard Next game: vs. Bears (Thursday, 12:30 p.m. ET) Colts Do the Colts still have a realistic shot at the postseason? The Colts entered the day in the eighth position among AFC playoff contenders and didn't help their case with a loss. After starting the day with a 34% shot at the playoffs, according to ESPN Analytics, the defeat lowered those chances to 27% independent of other outcomes. On the other hand, the Colts have one of the more favorable schedules down the stretch, with four of their five remaining opponents currently under .500. In any case, it will take significant work for them to reverse the damage done to their postseason hopes by losing four of their past five games. What we learned about the QB today: Sunday demonstrated that Anthony Richardson needs more help from his supporting cast. Indianapolis was flagged for a season-high eight offensive penalties, several of them proving to be crushing by negating big plays from the quarterback. Richardson also had some underwhelming performances from his pass targets, including a dropped touchdown by tight end Drew Ogletree . Eye-popping stat: This was the first loss in a game in which the Colts did not commit a turnover since a loss to the Raiders on Jan. 2, 2022. In the past five seasons, the Colts have 22 games in which they have avoided a turnover. They are now 19-3 in those contests. The Colts' six points Sunday is the fewest scored in any of those three losses. -- Stephen Holder Next game: at Patriots (Sunday, 1 p.m. ET) Tampa Bay 30, N.Y. Giants 7 Buccaneers Is this the jolt the Bucs needed to ignite a playoff push? Yes, as long as quarterback Baker Mayfield 's stinger isn't serious and these late-game fumbles stop. Getting franchise leading scorer Mike Evans back was huge. So was having both starting cornerbacks in Jamel Dean and Zyon McCollum , and the waiver wire pickup of safety Mike Edwards , who came in on third-down passing situations and then to relieve Jordan Whitehead after he had a pectoral injury in the fourth quarter. Only one of their remaining opponents -- the Chargers -- has a winning record. What we learned about the QB today: Mayfield still has some of that Oklahoma swag, or "spavalderia" if we're speaking Italian. Never mind the Bucs came into Sunday's game on a four-game losing streak. He hurdled Giants cornerback Cor'Dale Flott , did Giants quarterback Tommy DeVito 's signature celebration and sprinted downfield to deliver a block on Bucky Irving 's 56-yard run. Eye-popping stat: The Bucs had 11 different receiving targets catch passes, tied for their most in a game in franchise history. This was last done Week 16 of 2020, when Tom Brady threw for four touchdowns in a 47-7 win over the Lions, according to ESPN Research. -- Jenna Laine Next game: at Panthers (Sunday, 4:05 p.m. ET) Bucky Irving dances through the Giants defense for an impressive 56-yard gain for the Buccaneers. Giants How much did the release of Daniel Jones lead to this blowout loss? It's hard to imagine it wasn't a significant factor. The Giants benched their starting quarterback, saw him step in as a scout-team safety during a walk-through period at practice Thursday, and he was released by Friday. Players such as captain Dexter Lawrence II said publicly they thought Jones was still the team's best quarterback. Clearly, it had an effect. DeVito hardly provided the "spark" or energy that coach Brian Daboll thought it would while his team fell behind 23-0 by halftime. What we learned about the QB today: DeVito wasn't the answer. He went 3-of-5 passing for 31 yards with three sacks in the first half. He finished 21 of 31 passing for 189 yards. He was also sacked four times. Not that DeVito stood a chance. The Giants lost left tackle Jermaine Eluemunor on the opening drive. That put third-string left tackle Chris Hubbard into the game opposite Evan Neal for what was already the lowest-scoring offense in the NFL. Most surprising performance: A no-show by the Giants defense coming out of the bye week. Inexcusable. At points, Lawrence stood despondent, by himself, on the sideline. Perhaps it was because the defense barely sniffed Bucs quarterback Baker Mayfield during a sackless afternoon while allowing 400-plus yards of offense. -- Jordan Raanan Next game: at Cowboys (Thursday, 4:30 p.m. ET) Pittsburgh 24, Cleveland 19 Steelers Is this loss a wake up call for the Steelers offense? Don't be distracted by the first part of Russell Wilson 's stat line. Yes, the quarterback completed 21 of 28 attempts for 270 yards and a touchdown, but he was also sacked four times. And the offense had six empty possessions that ended either with a punt, turnover on downs or a turnover. Wilson had some moments of field-stretching brilliance, firing off three deep balls on third-down completions to Calvin Austin, Van Jefferson and George Pickens , but he also struggled against pressure. Winning like they did against the Ravens, with six Chris Boswell field goals, isn't sustainable. It wasn't against the Browns, and it won't be as the gauntlet of AFC North games continues. Describe the game in two words: Trap game. Hindsight is 20/20, but this had all the makings of a trap game. Though the Steelers said they didn't overlook the hapless Browns, they were clearly overpowered and outwitted by a motivated team playing with nothing to lose. Browns coach Kevin Stefanski took risks that paid off, while Steelers coach Mike Tomlin did the opposite. Eye-popping stat: Though they briefly erased their 12-point deficit, the Steelers are the only franchise that hasn't overcome a deficit of 12 or more points in the fourth quarter of a regular season game since 2000, per ESPN Research. -- Brooke Pryor Next game: at Bengals (Sunday, 1 p.m. ET) Browns Will the Browns play spoiler during the final stretch of the season? Thursday night's win over the Steelers marked the Browns' second upset victory over a divisional opponent, coming weeks after they stunned the Ravens. With four of its final six games coming against teams with winning records, Cleveland has the opportunity to play spoiler a few more times and a strong finish could raise optimism heading into the offseason with a roster that disappointed in the first half of the season. Describe the game in two words: No quit. Four days after giving up 21 points in the fourth quarter of a blowout loss to the Saints -- their seventh defeat in their previous eight games -- the Browns delivered a gritty victory at home against the division-leading Steelers. Most surprising performance: Browns offensive tackle Jack Conklin . The veteran lineman held outside linebacker T.J. Watt to just one pressure across 24 matchups. It was just the second game this season that Watt was held to one pressure. -- Daniel Oyefusi Next game: at Broncos (Monday, 8:15 p.m. ET)

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