p777 Patriots' coaches enter bye week confident Drake Maye can be a franchise quarterbackWOBURN, Mass., Nov. 21, 2024 (GLOBE NEWSWIRE) -- Replimune Group, Inc. (NASDAQ: REPL), a clinical stage biotechnology company pioneering the development of novel oncolytic immunotherapies, today announced that it has submitted a biologics license application (BLA) to the FDA for RP1 (vusolimogene oderparepvec) in combination with nivolumab for the treatment of adult patients with advanced melanoma who have previously received an anti-PD1 containing regimen. The submission was made under the Accelerated Approval pathway. The Company also announced that the FDA has granted Breakthrough Therapy designation to RP1 in combination with nivolumab in the same setting. Breakthrough Therapy designation is intended to expedite the development and review of therapies for serious diseases when preliminary clinical evidence indicates that the therapy may provide substantial improvement over existing available therapies on one or more clinically significant endpoints. This Breakthrough Therapy designation is based on the safety and clinical activity observed in the anti-PD1 failed melanoma cohort of the IGNYTE clinical trial. “Today is an important milestone for Replimune and for the melanoma community as we are one step closer to having another potential treatment available for patients who have limited options after progressing on anti-PD1 containing regimens,” said Sushil Patel, Ph.D., CEO of Replimune. The confirmatory Phase 3 IGNYTE-3 trial of RP1 in combination with nivolumab in advanced melanoma patients who have progressed on anti-PD1 and anti-CTLA-4 therapy, or who are not candidates for anti-CTLA-4 treatment is currently enrolling patients. For more information, visit https://replimune.com/clinical-trials/ignyte-3/ . About RP1 RP1 (vusolimogene oderparepvec) is Replimune’s lead product candidate and is based on a proprietary strain of herpes simplex virus engineered and genetically armed with a fusogenic protein (GALV-GP R-) and GM-CSF, intended to maximize tumor killing potency, the immunogenicity of tumor cell death, and the activation of a systemic anti-tumor immune response. About Replimune Replimune Group, Inc., headquartered in Woburn, MA, was founded in 2015 with the mission to transform cancer treatment by pioneering the development of novel oncolytic immunotherapies. Replimune’s proprietary RPx platform is based on a potent HSV-1 backbone intended to maximize immunogenic cell death and the induction of a systemic anti-tumor immune response. The RPx platform is designed to have unique dual local and systemic activity consisting of direct selective virus-mediated killing of the tumor resulting in the release of tumor derived antigens and altering of the tumor microenvironment to ignite a strong and durable systemic response. The RPx product candidates are expected to be synergistic with most established and experimental cancer treatment modalities, leading to the versatility to be developed alone or combined with a variety of other treatment options. For more information, please visit www.replimune.com . Forward Looking Statements This press release contains forward looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, including statements regarding our belief regarding the effect that the breakthrough designation will have on the timing and development of RP1 and other statements identified by words such as “could,” “expects,” “intends,” “may,” “plans,” “potential,” “should,” “will,” “would,” or similar expressions and the negatives of those terms. Forward-looking statements are not promises or guarantees of future performance, and are subject to a variety of risks and uncertainties, many of which are beyond our control, and which could cause actual results to differ materially from those contemplated in such forward-looking statements. These factors include risks related to our limited operating history, our ability to generate positive clinical trial results for our product candidates, the costs and timing of operating our in-house manufacturing facility, the timing and scope of regulatory approvals, the availability of combination therapies needed to conduct our clinical trials, changes in laws and regulations to which we are subject, competitive pressures, our ability to identify additional product candidates, political and global macro factors including the impact of the coronavirus as a global pandemic and related public health issues and the Russian-Ukrainian and Israel-Hamas political and military conflicts, and other risks as may be detailed from time to time in our Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q and other reports we file with the Securities and Exchange Commission. Our actual results could differ materially from the results described in or implied by such forward-looking statements. Forward-looking statements speak only as of the date hereof, and, except as required by law, we undertake no obligation to update or revise these forward-looking statements. Investor Inquiries Chris Brinzey ICR Healthcare 339.970.2843 chris.brinzey@westwicke.com Media Inquiries Arleen Goldenberg Replimune 917.548.1582 media@replimune.comA charity shop owner has been left heartbroken after his store was ruined by flooding from Storm Bert just four days after opening. Andrew Jones, 39, who runs Bacup Bargains in Rossendale - a community support hub - said the flood damage occurred on Saturday (November 23). In a desperate bid to prevent water from entering the premises, he used stock from the not-for-profit organisation, which had only opened its doors on Wednesday (November 20). Now, Andrew and his team of volunteers are faced with the task of cleaning up the shop, leaving him "devastated," , reports Lancs Live . READ MORE: "My community are good people": High-profile TikTokers speak out after young Travellers turned away from Manchester "I've been left devastated, truly devastated," he said. "When we got the building, we weren't aware of any flood risks. We did our research and found that there's been times where the water has got high up, but never to the point where it's flooded the buildings." He described the weekend's events as unprecedented, saying: "It was a whole new level on Saturday and Sunday, it's something that I've never seen before. We've had to do a good clean-up operation, we've had to put some more carpet down and buy new mats." The flooding has also impacted the business financially, as Andrew explained: "People haven't been able to come and visit the business, so we've lost money that way as well. We just want people to come and support us, so we can help them." The floods caused damage to stock He recalled how the floodwater became "deeper and deeper", leading him to use some of his stock to create a barrier. This decision resulted in a loss of £100 worth of items that could have been sold. Andrew said: "It started around dinnertime on Saturday, I saw it coming down the hill and thought that it wasn't normal. It got deeper and deeper but cars were still driving on the road, so it was pushing water into the business." He added: "We managed to use some clothes, which were our stock, so we have lost around £100 worth of stock as a result of the flooding. We also used some door mats that we were selling, so we tried to create a flood barrier with that." Gemma Lewis who works at The Waterloo pub on Rochdale Road in Bacup Andrew says that some of the drains near the shop were blocked with leaves, which is why he thinks it flooded the street so badly. "I went round and unblocked around 13 drains and within an hour, the water had gone," he said. "If the drains weren't so blocked up, then I think it could have been prevented." Local pub owner Pete Lewis, 44, who has been at the helm of The Waterloo in Bacup for approximately four months, also experienced significant flooding. He described how fast the situation deteriorated: "The rain started quite early in the morning and the snow started melting, so that was it. The drains got blocked up and couldn't handle it." As a result of the water ingress, he said, "The carpets have been ripped up and the beer barrels in the basement have been damaged - the whole place got flooded. "There wasn't much we could do because once it started going in through the cellar, it just filled the cellar up. Then it got worse and worse. "We aren't very happy about it but it's one of those things, it probably will happen again in the future."

KANSAS CITY, Mo. — Taylor Swift once raved about the sweet potato casserole served at a New York City restaurant and now that recipe pops up every now and again at Thanksgiving. The holidays encourage many of us to try new recipes. Social media right now is flooded with recipes for appetizers, side dishes and desserts. Anyone making that cornbread casserole from TikTok? While we might not get to share a Thanksgiving feast with Swift — is your name Blake Lively? — or other celebrities beloved by Kansas City, we can eat like them. So here’s the recipe for that casserole Swift loved so much, and favorite family side dish recipes from Donna Kelce and Eric Stonestreet. Enjoy. Travis Kelce's mother, Donna Kelce, seen here last year at her son's music festival, dined on a cheesesteak made by actor Bradley Cooper at QVC festivities in Las Vegas this week. (Emily Curiel/Kansas City Star/TNS) If we tried to guess how many holiday dinner rolls Travis Kelce and his brother, Jason Kelce, have scarfed over the years, would it be in the hundreds? Thousands? Their mom has spoken often about the batches of holiday crescent rolls she has baked over the years. Based on the recipe that won the 1969 Pillsbury Bake-Off, Pillsbury’s Magic Marshmallow Crescent Puffs , they’re now known as Mama Kelce’s Dinner Rolls. They blend the crescent roll pastry with marshmallows, cinnamon and sugar. Dinner roll or dessert? We bet they didn’t last long enough in front of Travis and Jason for that debate. Ingredients Rolls •1/4 cup granulated sugar •2 tablespoons Pillsbury Best all-purpose flour •1 teaspoon ground cinnamon •2 (8-ounce) cans refrigerated Pillsbury Original Crescent Rolls (8 Count) •16 large marshmallows •1/4 cup butter or margarine, melted Glaze •1/2 cup powdered sugar •1/2 teaspoon vanilla •2-3 teaspoons milk •1/4 cup chopped nuts Directions Make the rolls 1. Preheat oven to 375°F. Spray 16 medium muffin cups with nonstick baking spray. 2. In a small bowl, mix the granulated sugar, flour and cinnamon. 3. Separate the dough into 16 triangles. For each roll, dip 1 marshmallow into melted butter; roll in the sugar mixture. Place marshmallow on the shortest side of a triangle. Roll up, starting at shortest side and rolling to opposite point. Completely cover the marshmallow with the dough; firmly pinch edges to seal. Dip 1 end in remaining butter; place butter side down in muffin cup. 4. Bake for 12 to 15 minutes or until golden brown. 5. When done, remove from the oven and let the puffs cool in the pan for 1 minute. Remove rolls from muffin cups; place on cooling racks set over waxed paper. Make the glaze and assemble In a small bowl, mix the powdered sugar, vanilla and enough milk for desired drizzling consistency. Drizzle glaze over warm rolls. Sprinkle with nuts. Serve warm. Thanksgiving is one of the “Modern Family” star’s favorite holidays. Three years ago, as part of a campaign honoring hometown heroes , he shared one of his favorite recipe with McCormick Spices: Roasted Brussels Sprouts with Bacon and Butternut Squash . This recipe serves eight. Ingredients •1 pound Brussels sprouts, trimmed and halved •1 pound butternut squash, peeled and cut into bite-size cubes •1 tablespoon olive oil •1/2 teaspoon garlic powder •1/2 teaspoon thyme leaves •1/2 teaspoon salt •1/4 teaspoon ground black pepper •5 slices bacon, chopped •1 shallot, finely chopped •1/2 cup dried cranberries •1/4 cup balsamic vinegar •1 teaspoon whole grain mustard •1/2 cup chopped pecans, toasted (optional) •1/3 cup crumbled blue cheese, (optional) Directions 1. Preheat oven to 475°F. Spray large shallow baking pan with no stick cooking spray; set aside. Place Brussels sprouts and squash in large bowl. Drizzle with olive oil and sprinkle with garlic powder, thyme, salt and pepper; toss to coat evenly. Spread in single layer on prepared pan. 2. Roast 16 to 18 minutes or until tender and lightly browned, stirring halfway through cooking. 3. Meanwhile, cook bacon in medium skillet on medium heat about 6 minutes or until crispy. Remove using slotted spoon and place on paper towels to drain. Add shallot to same skillet; cook and stir 2 minutes until softened and lightly browned. Stir in cranberries, vinegar and mustard until well blended. Transfer mixture to small bowl; set aside. 4. Arrange roasted Brussels sprouts and squash on serving platter. Drizzle with cranberry balsamic glaze and toss gently to coat. Sprinkle with cooked bacon, toasted pecans, and crumbled blue cheese, if desired. Serve immediately. Swift gushed about the sweet potato casserole served at Del Frisco’s Grille in New York City, a dish crowned with a crunchy candied pecan and oatmeal crumble. “I’ve never enjoyed anything with the word casserole in it ever before, but it’s basically sweet potatoes with this brown sugary crust,” she told InStyle. ”Oh my God, it’s amazing.” The media rushed to find the recipe, which Parade has published this Thanksgiving season . “Similar to T. Swift herself, we think this recipe is a mastermind, especially if you’ve been asked to bring the sweet potato side dish to this year’s Thanksgiving feast. It seriously begs the question: who needs pumpkin pie?” the magazine writes. Ingredients •4 lbs sweet potatoes •1⁄3 cup oats •12 oz unsalted butter, divided •1⁄2 cup packed brown sugar •1⁄2 cup toasted pecans •1⁄2 cup granulated sugar •1 tsp kosher salt •2 tsp vanilla extract •4 large eggs, beaten Directions Preheat oven to 375°F. 1. Scrub sweet potatoes. Pierce each several times with a fork and wrap tightly in foil. Place on a sheet pan. Bake 90 minutes or until tender. Set aside until cool enough to handle. 2. Meanwhile, place oats in a food processor; process 1 minute. Add 4 oz butter, brown sugar and pecans; pulse five times to combine. Spread mixture on a baking sheet; bake 10 minutes. Remove from oven, crumble. Bake 5 minutes or until golden brown. 3. Melt remaining 8 oz butter. Remove skin from cooled sweet potatoes. In a large bowl, whisk sweet potatoes, melted butter, granulated sugar and remaining ingredients until slightly lumpy. Transfer to a greased baking dish, smoothing surface evenly. Top with oat mixture. Bake 12 minutes or until heated through. Make-ahead tips •Sweet potato filling can be made up to 2 days in advance. Prepare the sweet potato filling, cool, place in a casserole dish and keep refrigerated. •Oat-pecan crust can also be made up to 2 days ahead. Make the crust according to recipe directions, cool and store in an airtight container at room temperature. Sprinkle over the sweet potato filling just before baking. With our weekly newsletter packed with the latest in everything food.None

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PHILADELPHIA — Joel Embiid has missed 16 games this season because of left knee injury management, knee swelling, personal reasons and a three-game suspension. But after he misses his 17th contest against the Orlando Magic, the 2023 NBA MVP will start to wade into dangerous territory and be in jeopardy, once again, of being disqualified for regular-season awards. The NBA, in cooperation with the National Basketball Players Association, instituted a 65-game rule last season for awards, hoping it would deter players and teams from leaning on load management to take off games. The seven-time All-Star was disqualified last season after playing in only 39 games. The most games Embiid can play in this season is 65 if he participates in all of the remaining contests starting with Sunday’s game against the Bulls in Chicago. But that is highly unlikely since Embiid is not expected to play on back-to-back nights because of load management. Embiid, who has missed the last six games, is averaging career lows of 19.8 points, 7.5 rebounds and 1.0 block. He’s also registering career lows of 37.9% shooting from the field and 16.7% on 3-pointers. While he’ll remain sidelined, Paul George will return after a one game of load management to face the Magic (16-8) at the Wells Fargo Center. Meanwhile, center Andre Drummond (sprained right ankle) was upgraded to questionable after being scheduled to miss the game. His status change could be tied with reserve center Adem Bona being sidelined with a bruised left knee. The Sixers (5-15) will look to avenge Wednesday’s 106-102 loss to Orlando. ©2024 The Philadelphia Inquirer. Visit inquirer.com . Distributed by Tribune Content Agency, LLC.AKRON, Ohio (AP) — Nate Johnson scored 25 points to help Akron defeat Alabama State 97-78 on Sunday. Johnson added five rebounds for the Zips (4-2). Bowen Hardman scored 19 points, shooting 6 for 7 from beyond the arc. Isaiah Gray went 4 of 7 from the field to finish with 11 points. The Hornets (3-3) were led by CJ Hines with 19 points. Tyler Mack added 18 points and Antonio Madlock scored 17. Akron took the lead with 6:46 left in the first half and did not relinquish it. Johnson led their team in scoring with 13 points in the first half to help put them up 50-41 at the break. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .Booked AI Launches Beta Version, Promising a Smarter Way to Travel 11-25-2024 11:10 PM CET | IT, New Media & Software Press release from: Getnews / PR Agency: Brand Push The beta release introduces a seamless way to book flights, accommodations, and more using AI technology. Image: https://www.getnews.info/uploads/543d70bddf28632dd48a525fd5191612.jpg Booked AI, the first AI-powered travel agent accredited by IATA, has launched its beta version, offering a fresh approach to how travellers plan and book their journeys. Unlike traditional online travel agents, Booked AI manages the planning and booking process, designed to replicate the conversational experience of interacting with a human travel agent. Booked AI Founder Mennan Yelkenci said "the application is the start of a new era for booking travel, and a new era for AI which has not been powerful enough to make reservations for users before now.' Image: https://www.getnews.info/uploads/8f8950f89b6a055f184f13f5792c632e.jpg The platform distinguishes itself by enabling direct bookings for flights and accommodations, eliminating the need for third-party websites. Upcoming updates will expand its offerings to include tours, dining reservations, and activities, further streamlining the travel experience. "Booked AI aims to deliver the convenience of a personal travel agent at your fingertips," said Mennan Yelkenci, Founder and CEO of Booked AI. "This beta launch allows us to refine our platform based on user feedback while showcasing the future of AI-driven travel solutions." Image: https://www.getnews.info/uploads/138cfcb0f6921727be9655f9190c04a8.jpg Key Features of Booked AI: - Comprehensive Bookings: Users manage their entire trip in one place, from flights to accommodations. - Editable and shareable itineraries: Design, edit, and share itineraries effortlessly. - Direct Access: With IATA accreditation, Booked offers direct booking capabilities without intermediaries. Beta Testing and What's NextThe beta version is now open to the general public, offering an opportunity to explore the platform's innovative features. Feedback from users will guide the development of additional functionalities. A full-scale launch is planned for next year. Image: https://www.getnews.info/uploads/cefe8153749828da68228f455596704b.jpg People who are on the move regularly don't have time to waste when it comes to booking travel. Technology is making all areas of life quicker and easier, and that is what Booked AI does for travel. For more information or to sign up, visit https://www.booked.ai . Image: https://www.getnews.info/uploads/c0cf24d52d37b5feddef99625de06088.jpg About Booked AI Booked AI combines artificial intelligence with the functionality of a traditional travel agent to provide a comprehensive platform for planning and booking travel. As the first AI travel agent with IATA accreditation, it offers a streamlined approach to managing trips through advanced technology and direct booking features. Media Contact Company Name: Booked AI Contact Person: Mennan Yelkenci, Founder & CEO Email: Send Email [ http://www.universalpressrelease.com/?pr=booked-ai-launches-beta-version-promising-a-smarter-way-to-travel ] Phone: +61 436 815 589 Country: Australia Website: https://www.booked.ai This release was published on openPR.

The billing of London-born former Chelsea boss Hayes against England’s Dutch manager Sarina Wiegman – arguably the best two bosses in the women’s game – had generated more buzz in the build-up than the players on the pitch, despite it being a rare encounter between the two top-ranked sides in the world. Hayes enjoyed her return to familiar shores but felt the US lacked the “killer piece” after they looked the likelier side to make the breakthrough. Elite meeting of the minds 🌟 pic.twitter.com/R4d8EArqTp — U.S. Women's National Soccer Team (@USWNT) November 30, 2024 Asked what was going through her mind during the national anthem, Hayes said: “I was definitely mouthing (it), and Naomi (Girma) and Lynn (Williams) could see that I was struggling with where to be and all that. “I got to the end of the anthems and I thought, ‘that’s so ridiculous. I’m proud to be English and I’m proud of our national anthem, and I’m also really proud to coach America’. “Two things are possible all at once. I don’t want to fuel a nationalist debate around it. The realities are both countries are really dear to me for lots of reasons, and I’m really proud to represent both of them.” The Lionesses did not register a shot on target in the first half but grew into the game in the second. US captain Lindsey Horan had the ball in the net after the break but the flag was up, while Hayes’ side had a penalty award for a handball reversed after a VAR check determined substitute Yazmeen Ryan’s shot hit Alex Greenwood’s chest. Hayes, who left Chelsea after 12 trophy-packed years this summer, said: “I’ve been privileged to coach a lot of top-level games, including here, so there’s a familiarity to being here for me. “It’s not new to me, and because of that there was a whole sense of I’m coming back to a place I know. I have a really healthy perspective, and I want to have a really healthy perspective on my profession. “I give everything I possibly can for a team that I really, really enjoy coaching, and I thrive, not just under pressure, but I like these opportunities, I like being in these situations. They bring out the best in me. “You’ve got two top teams now, Sarina is an amazing coach, I thought it was a good tactical match-up, and I just enjoy coaching a high-level football match, to be honest with you. I don’t think too much about it.” Hayes had travelled to London without her entire Olympic gold medal-winning ‘Triple Espresso’ forward line of Trinity Rodman, Mallory Swanson and Sophia Smith, all nursing niggling injuries. Before the match, the 48-year-old was spotted chatting with Wiegman and her US men’s counterpart, fellow ex-Chelsea boss Mauricio Pochettino, who was also in attendance. England were also missing a number of key attackers for the friendly including Lauren Hemp, Lauren James and Ella Toone, all ruled out with injury. "This shows where we are at and we need to keep improving. It is November now. This is good but we want to be better again. We have to be better again." 👊 Reaction from the boss ⬇️ — Lionesses (@Lionesses) November 30, 2024 Wiegman brushed aside suggestions from some pundits that her side were content to settle for a draw. She said: “I think we were really defending as a team, very strong. We got momentum in the second half, we did better, and of course both teams went for the win. “So many things happened in this game, also in front of the goal, so I don’t think it was boring. “We wanted to go for the win, but it was such a high-intensity game, you have to deal with a very good opponent, so you can’t just say, ‘Now we’re going to go and score that goal’. “We tried, of course, to do that. We didn’t slow down to keep it 0-0. I think that was just how the game went.”