772 pub 777pub (BPT) - This article was sponsored and developed by Neurocrine Biosciences, Inc. Cerebral palsy (CP) is a neurodevelopmental disorder affecting movement and posture that begins in early childhood development. It is the most common cause of motor disability in children, affecting about one in 345 children in the United States. 1-2 It may happen as a result of lack of oxygen during or around birth, stroke, infection, a problem with metabolism or other problems that cause injury or affect the development of parts of the brain involved in movement control in the first few years of life. 3 CP is a permanent condition, affecting a person for their entire life. People living with CP typically have motor problems, which may include spasticity (abnormal muscle tightness), dyskinesia (uncontrolled movements) or ataxia (poor muscle control), and many people have a mix of these motor disorders. 4 Dyskinesia due to CP (DCP) is one of the most disabling forms of CP and impacts approximately 10% to 20% of people living with CP. 5-6 According to the Cerebral Palsy Foundation (CPF), the combination of irregular and unpredictable movements (chorea) and twisting and repeating movements (dystonia) often disrupt activities and cause significant functional impairment, including the ability to maintain balance, walk or fine motor control. 7 Heather Riordan, M.D., Neurologist and Movement Disorders Specialist, Director of the Phelps Center for Cerebral Palsy at the Kennedy Krieger Institute, discusses the symptoms of chorea and impact on patients in a video shared on the CPF website here . About 30% of people with DCP are affected mostly by these involuntary and irregular movements (chorea), while dystonia is the predominant motor finding in the remaining 70%. 8 However, it is common for both chorea and dystonia movements to be present together. 6 For people living with DCP, these movements can occur in any region of the body, including the arms and legs, torso and face and may vary in severity. They are often triggered or made worse by stimulation or stress. Because dyskinesia can occur at rest and/or when actively using the body, the problems with movement are very burdensome in day-to-day living, with discomfort and pain affecting the quality of life for people and their caregivers. 9 Jen Lyman, mom to a son with DCP, highlights how dyskinesia makes communicating more difficult. "The most difficult thing about dyskinesia is watching my son struggle to do things that he wants to do, but the extra movements get in the way...special things, such as using a touch screen to video chat with his grandmother, are nearly impossible despite his best efforts to use his hands and fingers. Something so simple, yet so special for him should be effortless." DCP has a wide-ranging impact on the individual, including lifelong challenges with movement, a higher risk of other medical issues, a higher rate of mental health challenges and difficulties with communication. 10-12 "Those of us who have the privilege to serve patients with dyskinetic, hyperkinetic or mixed cerebral palsy see the functional impact of this very challenging type of tone every day," said Susan Biffl, M.D., Rehabilitation Medicine Specialist at Rady Children's Hospital-San Diego and Assistant Professor at UC San Diego School of Medicine. "Patients face challenges with self-care, independence, mobility, communication, fine motor skills that affect occupational and recreational activities, swallowing, social interactions and even sleep. As this tone is variable, it is much more challenging to treat than more consistent tone issues, such as spasticity." Treatment Options There are currently no Food and Drug Administration-approved treatments for DCP. Dystonia and chorea are often managed separately as they respond differently to various treatments, which can make treatment challenging. 3 Most drugs being investigated for DCP have focused on dystonia, and more research is needed to determine potential treatments for chorea. New treatment options are needed to help manage these movement disorders and improve daily function and quality of life for those affected. "After 20 years of caring for individuals with cerebral palsy, I continue to find those with dyskinetic cerebral palsy among the most challenging to treat, largely due to the limited effectiveness of available pharmacologic options," said Joyce Oleszek, M.D., Professor, Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine. "There is an urgent need for more robust evidence to support pharmacologic treatments for this condition, given its profound impact on function, comfort and quality of life." Ongoing Research Clinical studies are important in the development of treatment options, allowing researchers to evaluate the safety and effectiveness of new medicines. The data from clinical studies are used to determine if an investigational treatment can be approved for use to treat certain disorders. There are ongoing clinical studies evaluating potential treatments for DCP, including one for chorea. Neurocrine Biosciences is conducting the KINECT ® -DCP clinical study, a Phase 3, randomized, double-blind placebo-controlled study investigating the study drug, valbenazine, for the treatment of DCP. The clinical study is currently enrolling children, adolescents and adults six to 70 years of age who have been diagnosed with DCP. "The Cerebral Palsy Foundation is excited to partner with Neurocrine Biosciences on this study," said Rachel Byrne, Executive Director of the Cerebral Palsy Foundation. "We are proud to support strong research that can potentially bring meaningful change to the lives of those living with cerebral palsy." If you or someone you know may be eligible for this research study, please visit the study website for additional information here: FindADCPStudy.com . REFERENCES Krigger KW. Cerebral palsy: a review. Am Fam Physician . 2006;73(1):91-100. Michael-Asalu A, Taylor G, Campbell H, Lelea LL, Kirby RS. Cerebral palsy: diagnosis, epidemiology, genetics, and clinical update. Adv Pediatr2019;66:189-208. doi:10.1016/j.yapd.2019.04.002 Monbaliu E, Himmelmann K, Lin JP, et al. Clinical presentation and management of dyskinetic cerebral palsy. Lancet Neurol. 2017;16(9):741-749. doi:10.1016/S1474-4422(17)30252-1 Christine C, Dolk H, Platt MJ, Colver A, Prasauskiene A, Krägeloh-Mann I; SCPE Collaborative Group. Recommendations from the SCPE collaborative group for defining and classifying cerebral palsy. Dev Med Child Neurol Suppl. 2007;109:35-38. doi:10.1111/j.1469-8749.2007.tb12626.x Lumsden DE, Crowe B, Basu A, et al. Pharmacological management of abnormal tone and movement in cerebral palsy. Arch Dis Child . 2019;104(8):775-780. doi:10.1136/archdischild-2018-316309 Monbaliu E, de Cock P, Ortibus E, Heyrman L, Klingels K, Feys H. Clinical patterns of dystonia and choreoathetosis in participants with dyskinetic cerebral palsy. Dev Med Child Neurol. 2016;58(2):138-144. doi:10.1111/dmcn.12846 Dyskinetic cerebral palsy. Cerebral Palsy Foundation. Published December 20, 2022. Accessed October 29, 2024. https://cpresource.org/understanding-cerebral-palsy/types-cerebral-palsy/dyskinetic-cerebral-palsy Himmelmann K, Hagberg G, Wiklund LM, Eek MN, Uvebrant P. Dyskinetic cerebral palsy: a population-based study of children born between 1991 and 1998. Dev Med Child Neurol. 2007;49(4):246-251. doi:10.1111/j.1469-8749.2007.00246.x Masson R, Pagliano E, Baranello G. Efficacy of oral pharmacological treatments in dyskinetic cerebral palsy: a systematic review. Dev Med Child Neurol . 2017; 59:1237-1248. doi:10.1111/dmcn.13532 What is cerebral palsy? Cerebral Palsy Foundation. Accessed November 13, 2024. https://cpresource.org/topic/what-cerebral-palsy Adults & adolescence. Cerebral Palsy Foundation. Accessed November 13, 2024. https://cpresource.org/topic/adults Communication. Cerebral Palsy Foundation. Accessed November 13, 2024. https://cpresource.org/topic/communication © 2024 Neurocrine Biosciences, Inc. All Rights Reserved. CAP-NBI-US-0115 12/2024 NBI-98854-DCP3018_11DecMatRelease_v1.0_25November2024

Staff Report Three weeks into the girls basketball season, Brandon Hanna has stepped down as Jefferson’s varsity girls basketball coach. “He resigned due to personal reasons,” Jefferson Superintendent John Montanaro said. The Falcons are 0-2 on the young season. TJ Furman, who coached Jefferson before Hanna took over this season, is the interim head coach for the rest of the year. “We’re lucky to have TJ come back and take over,” Montanaro said. Mel Hanna will continue to be the JV coach, according to Montanaro. Tuesday’s game against Madison was postponed. The Falcons are scheduled to host Edgewood Friday. In early November, Hanna resigned as Jefferson’s football coach, after four years in the position.

Bur Oak Resources Provides a Comprehensive Range of Affordable Solar Products in OntarioLucintel Forecasts the Global Adhesive in the Aerospace Market is expected to grow with a CAGR of 5.8% from 2024 to 2030 12-19-2024 11:50 PM CET | Business, Economy, Finances, Banking & Insurance Press release from: ABNewswire According to a market report by Lucintel, the future of the global adhesives in the aerospace market looks promising with opportunities in the original equipment manufacturer and maintenance, repair & operation markets. The global adhesive in the aerospac According to a market report by Lucintel, the future of the global adhesives in the aerospace market looks promising with opportunities in the original equipment manufacturer and maintenance, repair & operation markets. The global adhesive in the aerospace market According to a market report by Lucintel, the future of the global adhesives in the aerospace market [ https://www.lucintel.com/adhesives-in-aerospace-market.aspx ] looks promising with opportunities in the original equipment manufacturer and maintenance, repair & operation markets. The global adhesive in the aerospace market is expected to grow with a CAGR of 5.8% from 2024 to 2030. The major drivers for this market are rising production of commercial & military aircraft, growing focus on lightweight materials, and increasing demand for high-performance aerospace adhesives. A more than 150-page report to understand trends, opportunity and forecast in adhesives in the aerospace market to 2030 by resin type (epoxy, polyurethane, silicone, and other), technology (waterborne, solvent borne, and reactive), function (structural and non-structural), end use (original equipment manufacturer and maintenance, repair & operations), and region (North America, Europe, Asia Pacific, and the Rest of the World). Lucintel forecasts that epoxy is expected to witness the highest growth over the forecast period. Within this market, original equipment manufacturer is expected to witness higher growth. Download sample by clicking on adhesives in the aerospace market [ https://www.lucintel.com/adhesives-in-aerospace-market.aspx ] PPG Industries, Scigrip Adhesives, Hexcel Corporation, DuPont, Illinois Tool Works, Huntsman Corporation, Beacon Adhesives are the major suppliers in the adhesives in the aerospace market. This unique research report will enable you to make confident business decisions in this globally competitive marketplace. For a detailed table of contents, contact Lucintel at +1-972-636-5056 or write us at helpdesk@lucintel.com To get access of more than 1000 reports at fraction of cost visit Lucintel's Analytics Dashboard About Lucintel At Lucintel, we offer solutions for you growth through game changer ideas and robust market & unmet needs analysis. We are based in Dallas, TX and have been a trusted advisor for 1,000+ clients for over 20 years. We are quoted in several publications like the Wall Street Journal, ZACKS, and the Financial Times. Contact: Roy Almaguer Lucintel Dallas, Texas, USA Email: roy.almaguer@lucintel.com Tel. +1-972-636-5056 Explore Our Latest Publications Inventory Management Drone Market Last-Mile Deliver Drone Market Lithium Battery for Drone Market New Robotics and Drone Market Oil Plant Protection Drone Market Passenger Drone Market Media Contact Company Name: Lucintel Contact Person: Roy Almaguer Email:Send Email [ https://www.abnewswire.com/email_contact_us.php?pr=lucintel-forecasts-the-global-adhesive-in-the-aerospace-market-is-expected-to-grow-with-a-cagr-of-58-from-2024-to-2030 ] Phone: 972.636.5056 Address:8951 Cypress Waters Blvd., Suite 160 City: Dallas State: TEXAS Country: United States Website: https://www.lucintel.com/ This release was published on openPR.Bowls miss out in 4 CFP teams in latest postseason twist

Gandey (Giridih): The counting of votes for the 2024 Jharkhand Assembly elections begins on Saturday, with all eyes on the Gandey constituency in Giridih district. A crucial seat in the state, Gandey has witnessed intense competition this year, particularly between Kalpana Soren of the Jharkhand Mukti Morcha (JMM) and Muniya Devi of the Bharatiya Janata Party (BJP). The outcome is uncertain, as both parties have invested heavily in the region, with local issues and national politics fueling the electoral battle. In a state-wide election that saw a strong voter turnout of 68.01%, Gandey recorded an impressive 73.36% participation, underscoring the significance of this contest. Voting was conducted from 7 am to 6 pm on Wednesday, marking the end of an intense electoral exercise. Kalpana Soren, the sitting MLA and wife of Chief Minister Hemant Soren, is seeking re-election from Gandey. She has a solid track record, having won the seat in a by-election in May 2024 by a comfortable margin of over 27,000 votes. With strong local support, she remains a formidable contender, despite facing opposition from the BJP. Muniya Devi, a newcomer to mainstream politics, has been fielded by the BJP. Though relatively unknown at the state level, she has local experience, having served as the District Council member and president of the Jamua Council. Her entry into the BJP in 2023 has brought a fresh perspective to the party’s campaign in the region. Representing the Jharkhand Loktantrik Congress Morcha (JLKM), Md Aqueel Akhtar is seen as a lesser-known figure in the Gandey contest. His limited presence on the ground has made him less influential compared to the leading contenders. Bangladeshi Infiltration: One of the key issues dominating the Gandey election is the alleged infiltration of Bangladeshi nationals into the Santhal Pargana region. Hemant Soren has raised concerns about how this issue is affecting the tribal demographic. He has accused the BJP-led central government of not addressing illegal immigration, further politicizing the matter. Corruption Allegations: Corruption has been a major talking point for the BJP, with allegations against the ruling JMM government. The BJP has also criticized JMM's monthly cash transfer scheme, calling it ineffective and a tool for political manipulation, while JMM defends it as essential welfare for the poor. In the 2019 Jharkhand Assembly elections, the seat was won by Dr. Sarfaraz Ahmad of JMM, who defeated BJP’s Jai Prakash Verma by 8,855 votes.

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Promising lucrative returns through an “international investment scheme”, cyber fraudsters duped a Sector 16-based businessman of ₹ 57 lakh. The victim, Madhavjeet, filed a complaint with the Chandigarh Police cyber crime cell, narrating that the fraud began on May 9, when he enrolled in a “stock market training programme” promoted via Instagram. The ad featured a supposed expert, Rajat Chopra, claiming to compete in the Global Trading Championship (GTC) and offering opportunities to invest in an international trading account linked to Upstox. Initially, Madhavjeet said, he was asked to invest ₹ 10 lakh, which he transferred to various bank accounts in July. However, he became suspicious when he realised that the payments were being made to different accounts, not directly to Upstox. Upon contacting Upstox, he was informed that the platform had no affiliation with the scheme, but Chopra convinced him that his participation in GTC allowed for a separate international trading account. As the scheme progressed, Madhavjeet said, he was encouraged to invest further, with promises of high returns from IPO shares. When he expressed inability to pay ₹ 50 lakh for the IPO, Chopra offered a loan to facilitate the investment. But despite making large investments, his account never reflected the promised returns. By August, Madhavjeet said, he realised he had been thoroughly scammed after attempts to withdraw his funds were blocked unless he paid further amounts. A case under Sections 319 (2), 318 (4), 338, 336 (3), 340 (2) and 61 (2) of the BNS has been registered at the Cyber Crime police station against the unidentified accused.